CPT® Code 82135

Aminolevulinic acid, delta (ALA) is a biochemical compound that plays a crucial role in the porphyrin synthesis pathway, which is essential for the production of blood cells. The measurement of ALA levels in urine is performed through a specific test that can provide valuable insights into various medical conditions. Elevated levels of ALA in the urine may indicate the presence of acute porphyria, a group of disorders characterized by the accumulation of porphyrins, or hereditary tyrosinemia, a genetic disorder affecting the metabolism of the amino acid tyrosine. Additionally, ALA has applications in photodynamic therapy, where it acts as a photosensitizer, and it can also be utilized in the diagnosis of certain types of cancers. It is important to note that certain factors can influence the accuracy of the test results; for instance, alcohol ingestion must be avoided for at least 24 hours prior to the test, as it can lead to abnormally elevated ALA levels. Other substances, such as lead and various compounds, may also affect the test outcomes. The test is conducted by obtaining either a random urine sample or a 24-hour urine collection sample, which is then analyzed using quantitative ion exchange chromatography and spectrophotometry to determine the concentration of ALA present.