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The CPT® Code 82286 refers to a laboratory test specifically designed to measure the levels of bradykinin in the blood. Bradykinin is a biologically active peptide that plays a significant role in various physiological processes, including vasodilation, which is the widening of blood vessels, and the contraction of non-vascular smooth muscle found in areas such as the bronchial tubes and the gastrointestinal tract. Additionally, bradykinin is known to increase vascular permeability, allowing substances to pass through blood vessel walls more easily, and it is involved in the synthesis of prostaglandins, which are compounds that have various effects on the body, including inflammation and pain modulation. Bradykinin is typically broken down in the body by several enzymes, including angiotensin-converting enzyme (ACE), aminopeptidase P (APP), and carboxypeptidase N (CPN). Elevated levels of bradykinin can indicate certain medical conditions, particularly hereditary angioedema, a genetic disorder that causes severe swelling, as well as in patients experiencing tissue injury, chronic pain, or various inflammatory disorders. The test for bradykinin is performed on a blood sample, which is obtained through a procedure known as venipuncture. This sample is then analyzed using a method called enzyme-linked immunosorbent assay (ELISA), which is a common laboratory technique used to detect and quantify proteins, hormones, and other substances in biological samples.
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The bradykinin test (CPT® Code 82286) is indicated for the evaluation of various medical conditions where bradykinin levels may be relevant. The following conditions and symptoms may warrant this laboratory test:
The procedure for measuring bradykinin involves several key steps that ensure accurate results. First, a qualified healthcare professional performs a venipuncture, which is the process of puncturing a vein to obtain a blood sample. This step is crucial as it provides the necessary specimen for testing. Once the blood is collected, it is processed to separate the serum and/or plasma, which are the components of blood that will be analyzed for bradykinin levels. Following the collection and processing of the blood sample, the laboratory utilizes the enzyme-linked immunosorbent assay (ELISA) technique. This method involves adding specific antibodies that bind to bradykinin in the serum or plasma. The binding of bradykinin to these antibodies produces a measurable signal, which is then quantified to determine the concentration of bradykinin present in the sample. The entire procedure is designed to ensure that the results are reliable and can be used to inform clinical decisions regarding the patient's health status.
After the bradykinin test is completed, there are generally no specific post-procedure care requirements for the patient. However, it is important for the healthcare provider to monitor the patient for any potential complications related to the venipuncture, such as bruising or discomfort at the site of blood draw. Patients may resume their normal activities immediately following the procedure. The results of the bradykinin test will be analyzed and reported to the healthcare provider, who will interpret the findings in the context of the patient's clinical condition and determine any necessary follow-up actions or treatments based on the results.
| Short Descr | ASSAY OF BRADYKININ | Medium Descr | BRADYKININ | Long Descr | Bradykinin | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 1 | CCS Clinical Classification | 233 - Laboratory - Chemistry and Hematology |
| GA | Waiver of liability statement issued as required by payer policy, individual case | TC | Technical component; under certain circumstances, a charge may be made for the technical component alone; under those circumstances the technical component charge is identified by adding modifier 'tc' to the usual procedure number; technical component charges are institutional charges and not billed separately by physicians; however, portable x-ray suppliers only bill for technical component and should utilize modifier tc; the charge data from portable x-ray suppliers will then be used to build customary and prevailing profiles |
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| Pre-1990 | Added | Code added. |
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