© Copyright 2026 American Medical Association. All rights reserved.
The CPT® Code 82300 refers to a laboratory test specifically designed to measure the levels of cadmium in the body. Cadmium is classified as a transitional metal and is commonly found in various industrial settings, particularly in mining, smelting, and refining operations. Exposure to cadmium can occur through several routes, including inhalation of airborne particles, which is often a risk for workers in environments where cadmium is present. Additionally, individuals may be exposed to cadmium through smoking cigarettes, as tobacco plants can absorb cadmium from contaminated soil. Ingestion of food crops that have been grown in cadmium-contaminated soil or water is another potential source of exposure. Furthermore, cadmium can be absorbed through the skin, particularly from jewelry that contains high levels of this metal. Symptoms associated with cadmium exposure can vary widely and may include proteinuria (the presence of excess protein in urine), fever, headache, dyspnea (difficulty breathing), chest pain, sore throat, cough, conjunctivitis (inflammation of the eye), and rhinitis (inflammation of the nasal mucous membrane). In cases of cadmium toxicity, individuals may experience more severe symptoms such as vomiting, diarrhea, abdominal pain, and cramping. To conduct the test, a blood sample is collected, which is reported separately through a venipuncture procedure. Additionally, a urine sample is obtained, which can be collected either as a voided specimen or through catheterization, with options for random or 24-hour timed collection. The analysis of both blood and urine samples is performed using quantitative inductively coupled plasma-mass spectrometry, a highly sensitive technique that allows for accurate measurement of cadmium levels in biological samples.
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