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Official Description

Carotene

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 82380 refers to the laboratory test for measuring carotene levels in the blood. Carotene is a type of polyunsaturated hydrocarbon predominantly found in various plants, existing mainly in two isomeric forms: beta-carotene and alpha-carotene. These compounds are recognized for their antioxidant properties and are vital nutrients for human health. The measurement of carotene levels is significant as decreased levels can indicate potential health issues, such as inadequate dietary fat intake, the presence of intestinal parasites, certain fat malabsorption syndromes, and diseases affecting the kidney, liver, or pancreas. Additionally, certain medications can interfere with the absorption of carotenes, including cholestyramine, alcohol, fat-binding weight loss drugs, and fiber supplements. Conversely, elevated carotene levels may be associated with conditions such as hypothyroidism, diabetes, myxedema, chronic nephritis, and excessive intake of vitamin supplements. The test involves obtaining a blood sample through venipuncture, which is reported separately. The analysis of the blood serum is conducted to determine total carotene levels using quantitative spectrophotometry, while fractionated carotene levels (including alpha, beta, lutein, and zeaxanthin) can be assessed using qualitative high-performance liquid chromatography.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The carotene blood test (CPT® Code 82380) is indicated for various clinical scenarios where assessment of carotene levels is necessary. The following conditions may warrant this test:

  • Inadequate Dietary Intake Decreased carotene levels may suggest insufficient intake of dietary fats, which are essential for the absorption of fat-soluble vitamins and carotenoids.
  • Intestinal Parasites The presence of intestinal parasites can interfere with nutrient absorption, potentially leading to lower carotene levels.
  • Fat Malabsorption Syndromes Conditions that affect the body's ability to absorb fats, such as cystic fibrosis or celiac disease, may result in decreased carotene levels.
  • Kidney Diseases Certain kidney disorders can impact the metabolism and excretion of carotene, leading to altered serum levels.
  • Liver Diseases Liver function is crucial for the metabolism of various nutrients, including carotene; thus, liver diseases may affect carotene levels.
  • Pancreatic Diseases Disorders of the pancreas can also impair fat digestion and absorption, which may result in decreased carotene levels.
  • Hypothyroidism Elevated carotene levels may be indicative of hypothyroidism, where the metabolism of carotene is affected.
  • Diabetes Diabetes can lead to metabolic changes that may result in increased carotene levels.
  • Myxedema This condition, associated with severe hypothyroidism, may also present with elevated carotene levels.
  • Chronic Nephritis Chronic inflammation of the kidneys can alter carotene metabolism, potentially leading to elevated levels.
  • Excessive Vitamin Intake High intake of vitamin supplements, particularly those containing carotenoids, can result in elevated serum carotene levels.

2. Procedure

The procedure for measuring carotene levels involves several key steps that ensure accurate results. First, a blood sample is obtained from the patient through a process known as venipuncture. This procedure is performed by a qualified healthcare professional who will insert a needle into a vein, typically in the arm, to collect the blood sample. It is important to note that the venipuncture itself is a separately reportable procedure and should be documented accordingly. Once the blood sample is collected, it is processed to separate the serum or plasma from the cellular components. The serum is then subjected to quantitative spectrophotometry to measure total carotene levels. This method involves passing light through the serum sample and measuring the absorbance at specific wavelengths, which correlates with the concentration of carotene present. Additionally, if fractionated carotene levels are required, the serum or plasma may be analyzed using qualitative high-performance liquid chromatography (HPLC). This technique allows for the separation and identification of different carotene isomers, including alpha, beta, lutein, and zeaxanthin, providing a comprehensive profile of carotene levels in the sample.

3. Post-Procedure

After the blood sample has been collected and processed, there are generally no specific post-procedure care requirements for the patient. However, it is advisable for patients to maintain hydration and avoid strenuous activities immediately following venipuncture to minimize the risk of bruising or discomfort at the puncture site. The results of the carotene test will typically be available within a few days, and healthcare providers will discuss the findings with the patient during a follow-up appointment. It is important for patients to inform their healthcare provider of any medications they are taking, as certain drugs can affect carotene absorption and levels. Additionally, if the test results indicate abnormal carotene levels, further evaluation or additional testing may be warranted to determine the underlying cause and appropriate management strategies.

Short Descr ASSAY OF CAROTENE
Medium Descr CAROTENE
Long Descr Carotene
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 1
CCS Clinical Classification 233 - Laboratory - Chemistry and Hematology
90 Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number.
GY Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit
76 Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
GW Service not related to the hospice patient's terminal condition
Date
Action
Notes
Pre-1990 Added Code added.
Code
Description
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