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The CPT® Code 82528 refers to a laboratory test specifically designed to measure the levels of corticosterone in the blood. Corticosterone is a type of glucocorticoid hormone that is synthesized by the adrenal glands, which are located on top of each kidney. This hormone serves as a precursor to another important hormone known as aldosterone, which is classified as a mineralocorticoid. The secretion of corticosterone is regulated by the renin-angiotensin system, a hormone system that plays a crucial role in regulating blood pressure and fluid balance in the body. Additionally, corticosterone is involved in various physiological processes, including brain function and metabolism. In terms of its presence in the body, corticosterone is primarily found circulating in the bloodstream, with only minimal amounts stored in bodily tissues. To perform this test, a blood sample is collected through a procedure known as venipuncture, which is separately reportable. The analysis of the serum or plasma obtained from the blood sample is conducted using a sophisticated technique called quantitative high performance liquid chromatography-tandem mass spectrometry, which allows for precise measurement of corticosterone levels.
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The corticosterone test (CPT® Code 82528) is indicated for various clinical scenarios where assessment of adrenal function is necessary. The following conditions may warrant the performance of this test:
The procedure for measuring corticosterone levels involves several key steps that ensure accurate and reliable results. First, a healthcare professional will perform venipuncture, which is the process of inserting a needle into a vein to obtain a blood sample. This step is crucial as it allows for the collection of serum or plasma, which is necessary for the subsequent analysis. Once the blood sample is collected, it is processed to separate the serum or plasma from the cellular components of the blood. Following this, the sample is subjected to quantitative high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). This advanced analytical technique is employed to precisely measure the concentration of corticosterone in the sample. HPLC separates the components of the serum or plasma, while tandem mass spectrometry provides sensitive detection and quantification of corticosterone levels, ensuring that even low concentrations can be accurately assessed.
After the blood sample has been collected and processed, there are generally no specific post-procedure care requirements for the patient. However, it is important for the patient to be monitored for any immediate reactions to the venipuncture, such as bleeding or discomfort at the site of the needle insertion. The results of the corticosterone test will typically be available within a specified timeframe, depending on the laboratory's processing capabilities. Healthcare providers will interpret the results in the context of the patient's clinical condition and may recommend further testing or treatment based on the findings.
| Short Descr | ASSAY OF CORTICOSTERONE | Medium Descr | CORTICOSTERONE | Long Descr | Corticosterone | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 1 | CCS Clinical Classification | 233 - Laboratory - Chemistry and Hematology |
| 90 | Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number. | GY | Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit |
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| Pre-1990 | Added | Code added. |
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