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Official Description

Creatinine; clearance

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 82575 refers to the procedure for measuring creatinine clearance, which is a critical test used to assess kidney function. This procedure involves the collection of both a blood sample and a sample other than blood, typically urine, to evaluate the levels of creatinine. Creatinine is a waste product that results from the normal breakdown of creatine, a substance that muscles utilize to generate energy for contraction. The kidneys play a vital role in filtering out creatinine from the bloodstream, and thus, measuring its levels can provide valuable insights into renal health. Elevated creatinine levels may indicate impaired kidney function, making this test essential for screening and monitoring renal diseases. Additionally, creatinine levels are monitored in patients suffering from acute or chronic conditions that could potentially affect kidney function, as well as in those undergoing treatment with medications known to impact renal health. The measurement of creatinine is typically performed using spectrophotometry, a method that quantifies the concentration of creatinine in the samples. The creatinine clearance test (CPT® Code 82575) specifically calculates the creatinine content in relation to urine volume and the patient's physical size, serving as a general indicator of glomerular filtration rate (GFR), which is a key measure of kidney function.

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