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A laboratory test is conducted to assess the concentration of 11-Desoxycorticosterone, which is a precursor compound in the biosynthesis of mature corticosteroids. Corticosteroids and sex steroid hormones are synthesized by various glands in the body, including the adrenal glands, ovaries, testes, and placenta, from cholesterol. The production of these hormones involves a series of enzymatic reactions that can be disrupted at different stages, leading to hormonal imbalances. By measuring the levels of sex hormones and their precursor compounds, such as 11-Desoxycorticosterone, healthcare providers can aid in diagnosing conditions like congenital adrenal hyperplasia (CAH) and can also determine the specific type of CAH present. Following a diagnosis, this test is instrumental in monitoring the effectiveness of steroid replacement therapy and other therapeutic interventions. When a laboratory test for 11-Desoxycorticosterone is ordered, it is common practice to also measure additional hormones, including 11-deoxycortisol, corticosterone, 18-hydroxycorticosterone, cortisol, renin, aldosterone, and 17-hydroxyprogesterone. The test requires a blood sample, which is obtained through a venipuncture that is reported separately. The analysis of the serum or plasma is performed using quantitative high-performance liquid chromatography-tandem mass spectrometry, a sophisticated technique that allows for precise measurement of hormone levels.
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The laboratory test for 11-Desoxycorticosterone is indicated for several clinical scenarios, particularly in the evaluation and management of adrenal and hormonal disorders. The following conditions may warrant this test:
The procedure for obtaining a laboratory test for 11-Desoxycorticosterone involves several key steps that ensure accurate measurement and analysis of the hormone levels. The following procedural steps are typically followed:
After the procedure, patients may experience minimal discomfort at the venipuncture site, which typically resolves quickly. There are generally no specific post-procedure care instructions required for this test. However, patients should be informed about potential signs of complications, such as excessive bleeding or infection at the puncture site, and advised to contact their healthcare provider if such symptoms occur. The results of the test will be analyzed and interpreted by the healthcare provider, who will discuss the findings and any necessary follow-up actions with the patient.
| Short Descr | DESOXYCORTICOSTERONE | Medium Descr | DESOXYCORTICOSTERONE 11- | Long Descr | Desoxycorticosterone, 11- | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 1 | CCS Clinical Classification | 233 - Laboratory - Chemistry and Hematology |
| 90 | Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number. |
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| Pre-1990 | Added | Code added. |
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