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The CPT® Code 82670 refers to the laboratory test that measures the total amount of the hormone estradiol in the blood. Estradiol is a form of estrogen, which is a key hormone in the reproductive system, particularly in non-pregnant women. This test is crucial for evaluating ovarian function, as it helps in diagnosing various conditions such as precocious puberty, which is the onset of secondary sexual characteristics at an unusually early age, amenorrhea, the absence of menstruation, and gynecomastia, which is the enlargement of breast tissue in men. Additionally, estradiol levels are monitored in women undergoing in-vitro fertilization (IVF) to assess follicle development and in post-menopausal women receiving hormone replacement therapy to ensure appropriate hormone levels. The estradiol levels fluctuate throughout the menstrual cycle, reflecting the hormonal changes that occur during this time. After menopause, estradiol levels drop significantly, stabilizing at a very low but constant level. For menstruating women, normal estradiol levels range from 15 to 350 picograms per milliliter (pg/mL), while for postmenopausal women, the expected levels are less than 10 pg/mL. The test requires a blood sample, which is typically obtained through a venipuncture, a procedure that is separately reportable. Estradiol can be measured in either plasma or serum, and the measurement techniques include chemiluminescent immunoassay for pre-menopausal women and tandem mass spectrometry for males, children, and post-menopausal women.
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The estradiol test (CPT® Code 82670) is indicated for several clinical scenarios, particularly related to reproductive health and hormonal evaluation. The following conditions warrant the measurement of estradiol levels:
The procedure for measuring estradiol levels involves several key steps that ensure accurate results. The following outlines the procedural steps:
After the blood sample is collected, there are generally no specific post-procedure care requirements for the patient. However, patients may be advised to apply pressure to the venipuncture site to minimize any potential bruising. Results from the estradiol test are usually available within a few days, and the healthcare provider will discuss the findings with the patient, interpreting the results in the context of their overall health and any symptoms they may be experiencing. It is important for patients to follow up with their healthcare provider to understand the implications of their estradiol levels and any necessary next steps in their care.
| Short Descr | ASSAY OF TOTAL ESTRADIOL | Medium Descr | ASSAY OF TOTAL ESTRADIOL | Long Descr | Estradiol; total | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 1 | CCS Clinical Classification | 233 - Laboratory - Chemistry and Hematology |
| 90 | Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number. | 59 | Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25. | GA | Waiver of liability statement issued as required by payer policy, individual case | GY | Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit | 91 | Repeat clinical diagnostic laboratory test: in the course of treatment of the patient, it may be necessary to repeat the same laboratory test on the same day to obtain subsequent (multiple) test results. under these circumstances, the laboratory test performed can be identified by its usual procedure number and the addition of modifier 91. note: this modifier may not be used when tests are rerun to confirm initial results; due to testing problems with specimens or equipment; or for any other reason when a normal, one-time, reportable result is all that is required. this modifier may not be used when other code(s) describe a series of test results (eg, glucose tolerance tests, evocative/suppression testing). this modifier may only be used for laboratory test(s) performed more than once on the same day on the same patient. | GW | Service not related to the hospice patient's terminal condition | 77 | Repeat procedure by another physician or other qualified health care professional: it may be necessary to indicate that a basic procedure or service was repeated by another physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 77 to the repeated procedure or service. note: this modifier should not be appended to an e/m service. | Q4 | Service for ordering/referring physician qualifies as a service exemption | CR | Catastrophe/disaster related | GZ | Item or service expected to be denied as not reasonable and necessary | GV | Attending physician not employed or paid under arrangement by the patient's hospice provider | 26 | Professional component: certain procedures are a combination of a physician or other qualified health care professional component and a technical component. when the physician or other qualified health care professional component is reported separately, the service may be identified by adding modifier 26 to the usual procedure number. | 76 | Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service. | 95 | Synchronous telemedicine service rendered via a real-time interactive audio and video telecommunications system: synchronous telemedicine service is defined as a real-time interaction between a physician or other qualified health care professional and a patient who is located at a distant site from the physician or other qualified health care professional. the totality of the communication of information exchanged between the physician or other qualified health care professional and the patient during the course of the synchronous telemedicine service must be of an amount and nature that would be sufficient to meet the key components and/or requirements of the same service when rendered via a face-to-face interaction. modifier 95 may only be appended to the services listed in appendix p. appendix p is the list of cpt codes for services that are typically performed face-to-face, but may be rendered via a real-time (synchronous) interactive audio and video telecommunications system. | GX | Notice of liability issued, voluntary under payer policy | KX | Requirements specified in the medical policy have been met | PN | Non-excepted service provided at an off-campus, outpatient, provider-based department of a hospital | Q1 | Routine clinical service provided in a clinical research study that is in an approved clinical research study | QJ | Services/items provided to a prisoner or patient in state or local custody, however the state or local government, as applicable, meets the requirements in 42 cfr 411.4 (b) | QW | Clia waived test | XU | Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service |
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| 2021-01-01 | Changed | Code changed. |
| 2013-01-01 | Changed | Medium Descriptor changed. |
| Pre-1990 | Added | Code added. |
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