CPT® Code 82731

A semi-quantitative test for fetal fibronectin is conducted on cervicovaginal secretions to assess the risk of preterm labor. Fetal fibronectin (fFN) is a glycoprotein that acts as a biological adhesive, anchoring the fetal sac to the uterine lining during pregnancy. This protein is typically found in cervicovaginal secretions during the first 22 weeks of gestation, serving as an indicator of a healthy pregnancy. However, after this period, fetal fibronectin is generally absent until one to three weeks prior to labor onset. The presence of detectable levels of fetal fibronectin in women between 24 and 34 weeks of gestation, particularly when accompanied by symptoms indicative of preterm labor, suggests an elevated risk for preterm delivery. The test involves the collection of cervicovaginal secretions using a cotton swab, which are then analyzed to determine the presence or absence of fetal fibronectin, providing valuable information for managing pregnancy and potential preterm labor risks.