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Official Description

Fetal fibronectin, cervicovaginal secretions, semi-quantitative

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

A semi-quantitative test for fetal fibronectin is conducted on cervicovaginal secretions to assess the risk of preterm labor. Fetal fibronectin (fFN) is a glycoprotein that acts as a biological adhesive, anchoring the fetal sac to the uterine lining during pregnancy. This protein is typically found in cervicovaginal secretions during the first 22 weeks of gestation, serving as an indicator of a healthy pregnancy. However, after this period, fetal fibronectin is generally absent until one to three weeks prior to labor onset. The presence of detectable levels of fetal fibronectin in women between 24 and 34 weeks of gestation, particularly when accompanied by symptoms indicative of preterm labor, suggests an elevated risk for preterm delivery. The test involves the collection of cervicovaginal secretions using a cotton swab, which are then analyzed to determine the presence or absence of fetal fibronectin, providing valuable information for managing pregnancy and potential preterm labor risks.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The fetal fibronectin test is indicated for the following conditions:

  • Preterm Labor Symptoms Women exhibiting signs of preterm labor, such as regular contractions or cervical changes, may undergo this test to evaluate the risk of preterm delivery.
  • Gestational Age Between 24 and 34 Weeks The test is specifically utilized for pregnant women within this gestational age range to assess the likelihood of preterm birth.

2. Procedure

The procedure for conducting the fetal fibronectin test involves several key steps to ensure accurate results. First, a healthcare provider collects cervicovaginal secretions using a sterile cotton swab. This swab is gently inserted into the vagina to obtain a sample from the cervix, ensuring that the collection is done carefully to avoid any contamination. Once the sample is collected, it is placed in a designated container for testing. The sample is then analyzed in a laboratory setting, where the presence or absence of fetal fibronectin is determined through semi-quantitative testing methods. The results of this test provide critical information regarding the risk of preterm delivery, guiding further clinical management and decision-making for the patient.

3. Post-Procedure

After the fetal fibronectin test is performed, patients may be advised to continue monitoring for any signs of preterm labor. Depending on the results of the test, healthcare providers may recommend additional follow-up appointments or interventions to manage the pregnancy effectively. If fetal fibronectin is detected, further evaluation and potential treatment options may be discussed to mitigate the risk of preterm delivery. Patients should also be informed about the importance of reporting any new symptoms or changes in their condition to their healthcare provider promptly.

Short Descr ASSAY OF FETAL FIBRONECTIN
Medium Descr FTL FIBRONECTIN CERVICOVAG SECRETIONS SEMI-QUAN
Long Descr Fetal fibronectin, cervicovaginal secretions, semi-quantitative
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 1
CCS Clinical Classification 233 - Laboratory - Chemistry and Hematology
90 Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number.
Date
Action
Notes
1999-01-01 Added First appearance in code book in 1999.
Code
Description
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