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The glucose tolerance test (GTT) is a laboratory procedure designed to assess how well the body processes glucose, a vital sugar that serves as a primary energy source for cells. This test is particularly important in diagnosing conditions such as gestational diabetes, diabetes mellitus, and impaired glucose tolerance. It may also be utilized to evaluate lactose intolerance and malabsorption disorders. The test begins with the patient fasting for at least 8 hours to ensure accurate baseline measurements of blood glucose levels. A baseline blood sample is collected through venipuncture, which is a standard method for obtaining blood samples. Following this, the patient ingests a specified amount of concentrated glucose, typically 75 grams for non-pregnant individuals and 100 grams for pregnant patients, in the form of a drink known as Glucola. Subsequent blood samples are taken at designated intervals—60, 120, and 180 minutes post-ingestion—to monitor the body's glucose response. The plasma from these samples is analyzed using a quantitative enzymatic method to determine glucose levels. For testing related to lactose intolerance and malabsorption, a different protocol is followed, where a baseline sample is taken, and a 50-gram glucose dose is administered, with blood samples collected at 30, 60, 120, and 180 minutes. The first three blood samples collected during the GTT are reported using CPT® code 82951, while any additional samples beyond the initial three are reported using CPT® code 82952, which is specifically designated for each additional specimen collected during the test.
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