CPT® Code 82955

Glucose-6-phosphate dehydrogenase (G6PD) is a crucial enzyme that plays a significant role in the metabolic processes of red blood cells. It is essential for the proper functioning of the pentose phosphate pathway, which is vital for generating NADPH, a molecule that helps protect red blood cells from oxidative damage. A deficiency in G6PD can arise from genetic mutations located on the X chromosome, leading to a decreased level of this enzyme in the body. This deficiency can result in the abnormal breakdown of red blood cells, a condition known as hemolysis. In particular, neonates with G6PD deficiency may experience prolonged neonatal jaundice due to the increased destruction of red blood cells. Furthermore, individuals with G6PD deficiency are at risk of developing non-immune hemolytic anemia and may experience hemolytic crises triggered by various factors, including infections, certain foods such as fava beans, exposure to specific chemicals, or the use of certain medications. The CPT® Code 82955 specifically refers to the quantitative measurement of G6PD levels in the blood, which is performed by obtaining a blood sample and analyzing it using quantitative enzymatic methodology. This test is distinct from the screening test indicated by CPT® Code 82960, which utilizes the Beutler fluorescent spot test to detect the presence of G6PD in the blood.