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Official Description

Helicobacter pylori, blood test analysis for urease activity, non-radioactive isotope (eg, C-13)

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 83009 refers to a laboratory test specifically designed to analyze blood for urease activity using a non-radioactive isotope, such as Carbon-13 (C-13). This test is primarily utilized to diagnose infections caused by Helicobacter pylori, a bacterium that is commonly associated with various gastrointestinal conditions. H. pylori is known to inhabit the stomach, where it burrows into the gastric mucosa to access the less acidic epithelial cells. This bacterium produces an enzyme called urease, which plays a crucial role in its survival within the acidic environment of the stomach. The presence of H. pylori can lead to inflammation of the gastric lining, triggering an immune response that may result in chronic active gastritis, duodenal ulcers, or nonulcerative dyspepsia. The test involves collecting a baseline blood sample through a venipuncture, which is a separately reportable procedure. Following this, the patient ingests a solution containing C-13 urea. If H. pylori is present in the stomach, the urease enzyme will break down the C-13 urea, producing C-13 carbon dioxide (CO2). This CO2 is then absorbed into the bloodstream and subsequently exhaled, allowing for the detection of the infection through the analysis of the blood samples.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The Helicobacter pylori blood test (CPT® Code 83009) is indicated for the diagnosis of specific gastrointestinal conditions associated with H. pylori infection. The following conditions warrant the use of this test:

  • Chronic Active Gastritis This condition involves inflammation of the stomach lining that persists over time, often linked to H. pylori infection.
  • Duodenal Ulcer A duodenal ulcer is a sore that develops on the lining of the duodenum, the first part of the small intestine, which can be caused by H. pylori.
  • Nonulcerative Dyspepsia This term refers to persistent indigestion or discomfort in the upper abdomen without the presence of an ulcer, which may be associated with H. pylori infection.

2. Procedure

The procedure for conducting the Helicobacter pylori blood test involves several key steps that ensure accurate results. The following outlines the procedural steps:

  • Step 1: Baseline Blood Sample Collection Initially, a baseline blood sample is obtained from the patient through a venipuncture. This step is crucial as it serves as a reference point for subsequent analysis.
  • Step 2: Administration of C-13 Urea After the baseline sample is collected, the patient is instructed to orally ingest a solution containing C-13 urea. This non-radioactive isotope is essential for the detection of urease activity.
  • Step 3: Second Blood Sample Collection Following the ingestion of C-13 urea, a second blood sample is collected. This sample will be analyzed to determine the presence of C-13 carbon dioxide (CO2) in the bloodstream, which indicates urease activity linked to H. pylori.

3. Post-Procedure

After the completion of the Helicobacter pylori blood test, patients may be monitored for any immediate reactions to the ingestion of C-13 urea, although significant side effects are rare. The results from the blood samples will be analyzed to assess the presence of H. pylori infection. It is important for healthcare providers to communicate the results to the patient and discuss any necessary follow-up actions or treatments based on the findings. Additionally, proper documentation of the procedure and results is essential for accurate medical coding and billing.

Short Descr H PYLORI (C-13) BLOOD
Medium Descr HPYLORI BLOOD ANAL UREASE ACT NON-RADACT ISOTOPE
Long Descr Helicobacter pylori, blood test analysis for urease activity, non-radioactive isotope (eg, C-13)
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 1
CCS Clinical Classification 233 - Laboratory - Chemistry and Hematology
GV Attending physician not employed or paid under arrangement by the patient's hospice provider
GW Service not related to the hospice patient's terminal condition
Date
Action
Notes
2011-01-01 Changed Short description changed.
2005-01-01 Added First appearance in code book in 2005.
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