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Official Description

Hemoglobin; plasma

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 83051 refers to a laboratory test that measures the levels of hemoglobin present in the plasma. Hemoglobin is a vital protein primarily found within erythrocytes, commonly known as red blood cells, where it plays a crucial role in transporting oxygen throughout the body. However, certain medical conditions can lead to intravascular hemolysis, a process where red blood cells are destroyed, resulting in the release of hemoglobin into the plasma. This can occur due to various factors, including hereditary disorders, acquired conditions, or iatrogenic causes, which are related to medical interventions. When hemoglobin is released into the plasma, the body employs protective mechanisms to scavenge and manage the excess hemoglobin. However, if these mechanisms become overwhelmed, the concentration of free hemoglobin in the plasma can rise to levels that are detectable through laboratory testing. The test is performed by obtaining a blood sample through a procedure known as venipuncture, which is separately reportable. The analysis of the plasma hemoglobin is conducted using quantitative spectrophotometry, a method that measures the intensity of light absorbed by the hemoglobin in the plasma, providing an accurate quantification of its levels.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The hemoglobin plasma test (CPT® Code 83051) is indicated for various clinical scenarios where monitoring of hemoglobin levels in the plasma is necessary. The following conditions may warrant this test:

  • Intravascular Hemolysis This test is performed to evaluate patients suspected of experiencing intravascular hemolysis, where red blood cells are destroyed within the blood vessels, leading to the release of hemoglobin into the plasma.
  • Hereditary Conditions Patients with hereditary disorders that affect red blood cell stability or integrity may require this test to monitor hemoglobin levels and assess the severity of their condition.
  • Acquired Conditions Conditions acquired through various factors, such as infections, autoimmune diseases, or exposure to certain drugs, can lead to hemolysis, making this test essential for diagnosis and management.
  • Iatrogenic Causes The test may also be indicated in cases where hemolysis is a result of medical interventions, such as blood transfusions or certain surgical procedures, to ensure patient safety and monitor hemoglobin levels.

2. Procedure

The procedure for obtaining a plasma hemoglobin measurement involves several key steps, which are outlined as follows:

  • Step 1: Patient Preparation Prior to the blood draw, the patient may be instructed to follow specific guidelines, such as fasting or avoiding certain medications, to ensure accurate test results. However, specific preparation instructions are not detailed in the provided data.
  • Step 2: Venipuncture A qualified healthcare professional performs venipuncture, which involves inserting a needle into a vein, typically in the arm, to collect a blood sample. This step is crucial as it must be done carefully to avoid complications and ensure an adequate sample for testing.
  • Step 3: Sample Collection The blood collected during venipuncture is placed into a suitable container, often containing anticoagulants to prevent clotting. This ensures that the plasma can be separated from the cellular components of the blood for analysis.
  • Step 4: Plasma Separation After collection, the blood sample is processed in a laboratory setting, where it is centrifuged to separate the plasma from the red blood cells. The plasma, which contains the hemoglobin, is then prepared for testing.
  • Step 5: Quantitative Spectrophotometry The plasma is analyzed using quantitative spectrophotometry, a technique that measures the concentration of hemoglobin based on the absorption of light at specific wavelengths. This method provides an accurate quantification of plasma hemoglobin levels.

3. Post-Procedure

After the procedure, the patient may experience minor discomfort or bruising at the venipuncture site, which typically resolves quickly. There are no specific post-procedure care instructions provided in the data; however, patients are generally advised to keep the site clean and monitor for any signs of infection or excessive bleeding. The results of the plasma hemoglobin test will be interpreted by the healthcare provider, who will discuss the findings and any necessary follow-up actions based on the patient's clinical condition.

Short Descr HEMOGLOBIN PLASMA
Medium Descr HEMOGLOBIN PLASMA
Long Descr Hemoglobin; plasma
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 1
CCS Clinical Classification 233 - Laboratory - Chemistry and Hematology
90 Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number.
GY Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit
26 Professional component: certain procedures are a combination of a physician or other qualified health care professional component and a technical component. when the physician or other qualified health care professional component is reported separately, the service may be identified by adding modifier 26 to the usual procedure number.
91 Repeat clinical diagnostic laboratory test: in the course of treatment of the patient, it may be necessary to repeat the same laboratory test on the same day to obtain subsequent (multiple) test results. under these circumstances, the laboratory test performed can be identified by its usual procedure number and the addition of modifier 91. note: this modifier may not be used when tests are rerun to confirm initial results; due to testing problems with specimens or equipment; or for any other reason when a normal, one-time, reportable result is all that is required. this modifier may not be used when other code(s) describe a series of test results (eg, glucose tolerance tests, evocative/suppression testing). this modifier may only be used for laboratory test(s) performed more than once on the same day on the same patient.
GA Waiver of liability statement issued as required by payer policy, individual case
GW Service not related to the hospice patient's terminal condition
Q1 Routine clinical service provided in a clinical research study that is in an approved clinical research study
Q4 Service for ordering/referring physician qualifies as a service exemption
Date
Action
Notes
2023-01-01 Note Short and medium descriptions changed.
2013-01-01 Changed Medium Descriptor changed.
Pre-1990 Added Code added.
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