© Copyright 2026 American Medical Association. All rights reserved.
The CPT® Code 83069 refers to a laboratory test specifically designed to measure the presence of free hemoglobin in urine. Hemoglobin is a vital protein found in red blood cells (RBCs) that is responsible for transporting oxygen throughout the body. The presence of hemoglobin in urine, known as hemoglobinuria, can manifest in two primary forms: it may be visible as gross hematuria, where blood is apparent to the naked eye, or it may only be detectable through microscopic examination. Hemoglobinuria that includes RBCs typically indicates direct bleeding within the urinary tract, which can arise from various underlying conditions. Conversely, hemoglobinuria without the presence of RBCs suggests a rapid increase in free hemoglobin levels in the bloodstream, prompting the kidneys to excrete the excess. This condition can be associated with several medical issues, including kidney infections, inflammation, tumors, severe burns, malaria, hemolytic uremic syndrome, sickle cell disease, transfusion reactions, thrombocytopenic purpura, and hemolytic anemia. To perform this test, a urine sample is collected from the patient, either through random voiding or catheterization, and the analysis is conducted using quantitative spectrophotometry, a method that quantifies the concentration of hemoglobin in the urine sample.
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