CPT® Code 83586

The CPT® Code 83586 refers to a laboratory test specifically designed to measure the total concentration of 17-ketosteroids (17-KS) in urine. 17-ketosteroids are a group of steroid hormones that are produced as metabolites from adrenal hormones, including cortisol, cortisone, 11-desoxycortisol, and deoxycorticosterone, along with their tetrahydroderivatives. The presence of an hydroxyl group and a short carbon chain at the 17 position on the steroid nucleus characterizes these compounds. This test is particularly significant in the evaluation of various endocrine disorders. Elevated levels of 17-KS can indicate conditions such as adrenal hyperplasia, which may lead to precocious puberty, Cushing syndrome, obesity, and other pathological stress conditions like acute illness, infection, surgery, or burns. Conversely, decreased levels of 17-KS may suggest adrenal insufficiencies, such as Addison's disease, adrenocorticotropic hormone (ACTH) deficiency, or hypopituitarism. The test is conducted using a 24-hour urine sample, which is analyzed through quantitative spectrophotometry to ensure accurate measurement of the total 17-ketosteroids present. For more specific measurements, such as fractionated 17-ketosteroids, the CPT® Code 83593 should be utilized.