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The CPT® Code 83625 refers to the laboratory test for lactate dehydrogenase (LD) isoenzymes, specifically focusing on their separation and quantitation. Lactate dehydrogenase (LDH) is an important enzyme that plays a critical role in the metabolic process, particularly in the conversion of lactate to pyruvate. This enzyme is found in various tissues throughout the body, including red blood cells (RBCs), heart, liver, pancreas, kidneys, skeletal muscle, brain, and lungs. The presence of LDH in these tissues means that it can serve as a valuable biomarker for tissue damage or disease. LDH exists in five distinct isoenzymes, each with a unique structure and distribution across different organs. These isoenzymes are categorized as LDH-1, LDH-2, LDH-3, LDH-4, and LDH-5. LDH-1 is predominantly located in heart muscle and red blood cells, making it particularly relevant in diagnosing cardiac conditions. LDH-2 is primarily found in white blood cells, while LDH-3 is associated with lung tissue. LDH-4 is present in the kidney, placenta, and pancreas, and LDH-5 is mainly found in the liver and skeletal muscle. By measuring the levels of these specific LDH isoenzymes, healthcare providers can gain insights into the location and extent of tissue damage, which can aid in diagnosing various medical conditions. The test is performed by obtaining a blood sample through venipuncture, and the serum is then analyzed using quantitative enzymatic methodology and electrophoresis to separate and quantify each isoenzyme individually.
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The lactate dehydrogenase (LDH) isoenzyme test, represented by CPT® Code 83625, is indicated for various clinical scenarios where tissue damage or disease is suspected. The following conditions may warrant this test:
The procedure for conducting the lactate dehydrogenase isoenzyme test involves several key steps to ensure accurate results. First, a blood sample is obtained from the patient through a process known as venipuncture. This involves inserting a needle into a vein, typically in the arm, to collect the necessary blood volume. The blood sample is then placed in a suitable container for serum separation.
After the lactate dehydrogenase isoenzyme test is completed, the patient may experience minimal discomfort at the venipuncture site, which typically resolves quickly. There are no specific post-procedure care instructions required for this test, as it is a routine laboratory procedure. However, healthcare providers may advise patients to monitor the site for any unusual swelling or bruising. The results of the test will be analyzed and interpreted by a qualified healthcare professional, who will discuss the findings with the patient and determine any necessary follow-up actions based on the isoenzyme levels detected.
| Short Descr | ASSAY OF LDH ENZYMES | Medium Descr | LACTATE DEHYDROGENASE ISOENZYMES SEP&QUAN | Long Descr | Lactate dehydrogenase (LD), (LDH); isoenzymes, separation and quantitation | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 1 | CCS Clinical Classification | 233 - Laboratory - Chemistry and Hematology |
| 90 | Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number. | 59 | Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25. | GA | Waiver of liability statement issued as required by payer policy, individual case | GW | Service not related to the hospice patient's terminal condition | GY | Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit |
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| Pre-1990 | Added | Code added. |
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