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Official Description

Lipoprotein, blood; quantitation of lipoprotein particle number(s) (eg, by nuclear magnetic resonance spectroscopy), includes lipoprotein particle subclass(es), when performed

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 83704 refers to a laboratory test that quantifies lipoprotein particle numbers in the blood, utilizing nuclear magnetic resonance (NMR) spectroscopy. Lipoproteins are complex biochemical structures composed of lipid molecules bound to proteins, playing a crucial role in the transport of fats throughout the body via the bloodstream. These lipoproteins vary in size and density, ranging from large, less dense particles, which contain more fat than protein, to smaller, denser particles, which have a higher protein content relative to fat. They can originate from dietary sources (exogenous) or be synthesized by the liver (endogenous). The test involves obtaining a blood sample through a procedure known as venipuncture, which is separately reportable. The process of quantifying lipoproteins can involve various techniques. For instance, CPT® Code 83700 describes a method where lipoproteins are separated using electrophoresis, a technique that employs an electrical field to segregate lipoprotein molecules, which are then stained and quantified. Alternatively, CPT® Code 83701 details a more advanced method involving high-resolution fractionation and quantitation of lipoproteins, which may include techniques such as quantitative electrophoresis or ultracentrifugation. In ultracentrifugation, lipoproteins are separated based on their hydrated densities, utilizing salts for fractionation, followed by centrifugation to distinguish between very low-density, low-density, and high-density lipoproteins, with subsequent quantification of each type. CPT® Code 83704 specifically highlights the use of NMR spectroscopy for the quantitation of lipoprotein particle numbers and subclasses. This sophisticated technique allows for the detection of lipoprotein particles of varying sizes, facilitating a detailed quantification of both the total number of lipoprotein particles and their subclasses. This information is particularly valuable in the assessment and management of patients with elevated triglyceride levels and in evaluating cardiovascular disease risk, especially in individuals with diabetes.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The procedure associated with CPT® Code 83704 is indicated for the assessment of lipoprotein levels in patients who may be at risk for cardiovascular diseases or metabolic disorders. The following conditions and symptoms may warrant this test:

  • Cardiovascular Disease Risk Assessment Patients with a family history of cardiovascular disease or those exhibiting risk factors such as hypertension, hyperlipidemia, or diabetes may require this test to evaluate their lipoprotein profiles.
  • Management of Elevated Triglyceride Levels Individuals presenting with elevated triglyceride levels may benefit from this test to better understand their lipoprotein particle composition and to guide treatment decisions.
  • Monitoring of Lipid Disorders Patients diagnosed with lipid disorders may need regular monitoring of their lipoprotein particle numbers and subclasses to assess the effectiveness of therapeutic interventions.

2. Procedure

The procedure for CPT® Code 83704 involves several key steps to ensure accurate quantitation of lipoprotein particle numbers and subclasses:

  • Step 1: Patient Preparation Prior to the blood draw, the patient may be instructed to fast for a specified period to ensure accurate lipid measurements. This preparation helps to minimize the influence of recent dietary intake on lipoprotein levels.
  • Step 2: Blood Sample Collection A qualified healthcare professional performs venipuncture to obtain a blood sample from the patient. This step is critical as it provides the specimen needed for subsequent analysis.
  • Step 3: Laboratory Analysis The collected blood sample is sent to a laboratory where it undergoes analysis using nuclear magnetic resonance (NMR) spectroscopy. This advanced technique allows for the detection and quantification of lipoprotein particles based on their size and density.
  • Step 4: Data Interpretation After the analysis, the laboratory generates a report detailing the number of lipoprotein particles and their subclasses. Healthcare providers will interpret these results in the context of the patient's overall health and risk factors.

3. Post-Procedure

After the procedure associated with CPT® Code 83704, patients may experience minimal discomfort at the venipuncture site, which typically resolves quickly. There are no specific post-procedure care requirements; however, patients should be advised to monitor the site for any signs of excessive bleeding or infection. The results of the lipoprotein quantitation will be discussed with the patient during a follow-up appointment, where healthcare providers will outline any necessary lifestyle modifications or treatment plans based on the findings. Regular monitoring may be recommended for patients with identified risk factors or existing conditions related to lipid metabolism.

Short Descr LIPOPROTEIN BLD QUAN PART
Medium Descr LIPOPROTEIN BLOOD QUAN NUMBERS & SUBCLASSES
Long Descr Lipoprotein, blood; quantitation of lipoprotein particle number(s) (eg, by nuclear magnetic resonance spectroscopy), includes lipoprotein particle subclass(es), when performed
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 1
CCS Clinical Classification 233 - Laboratory - Chemistry and Hematology
90 Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number.
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
GA Waiver of liability statement issued as required by payer policy, individual case
GZ Item or service expected to be denied as not reasonable and necessary
91 Repeat clinical diagnostic laboratory test: in the course of treatment of the patient, it may be necessary to repeat the same laboratory test on the same day to obtain subsequent (multiple) test results. under these circumstances, the laboratory test performed can be identified by its usual procedure number and the addition of modifier 91. note: this modifier may not be used when tests are rerun to confirm initial results; due to testing problems with specimens or equipment; or for any other reason when a normal, one-time, reportable result is all that is required. this modifier may not be used when other code(s) describe a series of test results (eg, glucose tolerance tests, evocative/suppression testing). this modifier may only be used for laboratory test(s) performed more than once on the same day on the same patient.
GY Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit
GW Service not related to the hospice patient's terminal condition
GX Notice of liability issued, voluntary under payer policy
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
Date
Action
Notes
2017-01-01 Changed Long, Medium and Short descriptions changed.
2011-01-01 Changed Short description changed.
2006-01-01 Added First appearance in code book in 2006.
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