CPT® Code 83884

Neurofilament light chain (NfL) is a significant biomarker that indicates the level of neuronal axon degeneration occurring in the subcortex of the brain. Elevated levels of NfL can be detected in both plasma and cerebrospinal fluid (CSF) and are associated with various neurodegenerative disorders, including Alzheimer's disease, multiple sclerosis, frontotemporal dementia, and amyotrophic lateral sclerosis. The presence of NfL in the blood is particularly noteworthy, as it is typically not found in significant amounts under normal conditions. This biomarker is released into the CSF during neuronal injury and subsequently enters the bloodstream. The plasma-based assay for NfL is particularly valuable in clinical settings, as it aids in differentiating whether a decline in cognitive function is attributable to a neurodegenerative disorder. Traditional testing methods primarily utilize CSF samples; however, advancements have led to the development of blood tests that can detect NfL levels. These blood-based tests not only streamline the diagnostic process by potentially reducing the need for more invasive procedures but also serve as effective tools for monitoring disease progression and evaluating treatment responses in patients with neurodegenerative conditions.