© Copyright 2026 American Medical Association. All rights reserved.
The CPT® Code 84075 refers to a laboratory test that measures the levels of alkaline phosphatase (ALP) in the blood. Alkaline phosphatase is a type of hydrolase enzyme that plays a crucial role in the removal of phosphate groups from various molecules. This enzyme is predominantly found in several tissues throughout the body, including the liver, bile ducts, kidneys, bones, and placenta. The measurement of ALP levels is significant because elevated levels can indicate various medical conditions, such as bile duct obstruction, Paget's disease, and certain types of tumors known as seminomas. Conversely, decreased levels of alkaline phosphatase may be associated with conditions such as hypophosphatasia, which is a genetic disorder, Wilson's disease, specific types of anemia or leukemia, and other factors such as postmenopausal estrogen therapy for osteoporosis, oral contraceptive use, cardiac surgery recovery in men, malnutrition, hypothyroidism, and certain pediatric conditions like achondroplasia, cretinism, or severe enteritis. The test is performed by obtaining a blood sample through venipuncture, which is a separate reportable procedure. The analysis of alkaline phosphatase levels is conducted using quantitative enzymatic methodologies on serum and/or plasma samples, providing essential information for diagnosing and monitoring various health conditions.
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