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Official Description

Phosphatidylglycerol

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 84081 refers to the assessment of fetal lung maturity through the testing of phosphatidylglycerol (PG). Phosphatidylglycerol is a specific type of lipid that becomes detectable in the amniotic fluid only when the fetal lungs have reached maturity. This testing is crucial as it helps healthcare providers evaluate the likelihood of neonatal respiratory distress syndrome (RDS), which is also known as hyaline membrane disease, occurring after the baby is born. The presence of PG in the amniotic fluid indicates that the lungs are sufficiently developed, thereby reducing the risk of RDS. The test is typically conducted on amniotic fluid collected prior to delivery, and its results can influence clinical decisions regarding the management of premature labor. Specifically, the test helps determine whether to suppress premature labor or to allow the delivery to proceed based on the maturity of the fetal lungs. Additionally, this test may be indicated in situations where there are complications affecting the health of the mother and/or fetus, guiding the decision on whether it is safe to induce labor. The assay for PG is performed using a method known as latex agglutination, which is a reliable technique for detecting the presence of this lipid in the amniotic fluid. If phosphatidylglycerol is found, it suggests a low risk of neonatal respiratory distress syndrome, providing reassurance to both the healthcare team and the family.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The test for phosphatidylglycerol (PG) is indicated in several clinical scenarios related to fetal lung maturity and the management of premature labor. The following are the specific indications for performing this test:

  • Assessment of Fetal Lung Maturity - The primary indication for testing PG is to evaluate the maturity of the fetal lungs, which is critical for determining the risk of neonatal respiratory distress syndrome (RDS) after delivery.
  • Management of Premature Labor - The test helps in deciding whether to suppress premature labor based on the maturity of the fetal lungs, which can influence the timing of delivery.
  • Induction of Labor - In cases where there are complications affecting the health of the mother and/or fetus, the PG test can determine if the fetal lungs are mature enough to safely induce labor.

2. Procedure

The procedure for testing phosphatidylglycerol involves several key steps that ensure accurate assessment of fetal lung maturity. The following outlines the procedural steps:

  • Collection of Amniotic Fluid Sample - A separately reportable sample of amniotic fluid is obtained, typically through an amniocentesis procedure. This involves inserting a thin needle through the abdominal wall into the uterus to collect the fluid surrounding the fetus.
  • Performance of PG Assay - The collected amniotic fluid sample undergoes a phosphatidylglycerol assay, which is performed using the latex agglutination method. This technique involves mixing the amniotic fluid with latex particles coated with antibodies specific to phosphatidylglycerol. If PG is present, it will cause the latex particles to agglutinate, indicating a positive result.

3. Post-Procedure

After the procedure, the healthcare provider will monitor the patient for any potential complications related to the amniocentesis, such as bleeding or infection. The results of the PG test will be interpreted in the context of the patient's clinical situation. If phosphatidylglycerol is detected in the amniotic fluid, it suggests that the fetal lungs are mature, indicating a low risk of neonatal respiratory distress syndrome. This information will guide further management decisions regarding labor and delivery, ensuring that both maternal and fetal health are prioritized.

Short Descr ASSAY PHOSPHATIDYLGLYCEROL
Medium Descr PHOSPHATIDYLGLYCEROL
Long Descr Phosphatidylglycerol
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 1
CCS Clinical Classification 233 - Laboratory - Chemistry and Hematology
Date
Action
Notes
2013-01-01 Changed Short Descriptor changed.
Pre-1990 Added Code added.
Code
Description
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