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The evaluation of cervicovaginal fluid for specific amniotic fluid proteins is a diagnostic procedure utilized primarily when there is a suspicion of premature rupture of membranes (PROM). This condition can lead to significant complications during pregnancy, making timely and accurate diagnosis crucial. The proteins assessed in this evaluation include placental alpha microglobulin-1 (PAMG-1), placental protein 12 (PP12), and alpha-fetoprotein (AFP). PAMG-1 is a protein that is produced in the fetal liver and yolk sac, and its concentration in amniotic fluid increases significantly during the second and third trimesters of pregnancy. PP12, on the other hand, is synthesized by the placental decidua and reaches its peak levels in the amniotic fluid during the first trimester, remaining elevated until delivery. AFP is another important protein that is initially produced by the yolk sac in early gestation and subsequently by the fetal liver and gastrointestinal tract. The testing process involves swabbing the cervix and vagina to collect cervicovaginal secretions, which are then analyzed using immunoassay techniques. These techniques employ a series of monoclonal and/or polyclonal antibodies to detect the presence of one or more of these specific proteins. The results of this evaluation can provide critical information regarding the integrity of the amniotic sac and help guide clinical decision-making in the management of the pregnancy.
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The evaluation of cervicovaginal fluid for specific amniotic fluid proteins is indicated in the following situations:
The procedure for evaluating cervicovaginal fluid for specific amniotic fluid proteins involves several key steps:
Post-procedure care typically involves monitoring the patient for any signs of complications related to PROM, such as infection or labor. The healthcare provider may provide guidance on follow-up care and any necessary interventions based on the test results. It is essential to ensure that the patient is informed about the implications of the test results and any further steps that may be required in the management of their pregnancy.
| Short Descr | EVAL AMNIOTIC FLUID PROTEIN | Medium Descr | EVAL C/V AMNIOTIC FLUID PROTEIN QUAL EA SPECIMEN | Long Descr | Evaluation of cervicovaginal fluid for specific amniotic fluid protein(s) (eg, placental alpha microglobulin-1 [PAMG-1], placental protein 12 [PP12], alpha-fetoprotein), qualitative, each specimen | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 1 | CCS Clinical Classification | 233 - Laboratory - Chemistry and Hematology |
| 26 | Professional component: certain procedures are a combination of a physician or other qualified health care professional component and a technical component. when the physician or other qualified health care professional component is reported separately, the service may be identified by adding modifier 26 to the usual procedure number. | 90 | Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number. |
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| 2014-01-01 | Changed | Description Changed |
| 2011-01-01 | Added | Added |
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