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Official Description

Protoporphyrin, RBC; screen

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 84203 refers to a laboratory test specifically designed to measure the levels of protoporphyrin in red blood cells (RBC). Protoporphyrin is a crucial biochemical molecule involved in the synthesis of heme, which is an essential component of hemoglobin in red blood cells. This test is particularly significant in diagnosing various conditions related to the heme biosynthesis pathway. Elevated levels of protoporphyrin can indicate several underlying health issues, including genetic disorders that affect heme production and exposure to toxic substances such as lead. One of the most prevalent causes of increased protoporphyrin levels in red blood cells is iron deficiency anemia, a condition where the body lacks sufficient iron to produce healthy red blood cells. Additionally, conditions such as erythropoietic protoporphyria (EPP) and certain porphyrias linked to heavy metals, solvents, and medications can also lead to elevated protoporphyrin levels. The test is particularly useful when total RBC porphyrins are elevated, as it helps differentiate between iron-deficiency anemia and other potential causes of increased porphyrin levels, thereby guiding appropriate clinical management and treatment strategies.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The CPT® Code 84203 is indicated for use in the following scenarios:

  • Iron Deficiency Anemia - The test is performed to evaluate patients suspected of having iron deficiency anemia, which is characterized by low iron levels leading to increased protoporphyrin in red blood cells.
  • Erythropoietic Protoporphyria (EPP) - This test is utilized in the diagnosis of EPP, a genetic disorder that results in the accumulation of protoporphyrin in the body.
  • Lead Exposure - The test is indicated for individuals who may have been exposed to lead, as lead toxicity can disrupt heme synthesis and lead to elevated protoporphyrin levels.
  • Porphyrias - It is also indicated for assessing porphyrias caused by heavy metals, solvents, and certain medications, which can result in increased protoporphyrin levels.

2. Procedure

The procedure for performing the test associated with CPT® Code 84203 involves several key steps:

  • Sample Collection - A blood sample is drawn from the patient, typically from a vein in the arm, using standard venipuncture techniques. The collected blood is then placed in a suitable container for laboratory analysis.
  • Laboratory Analysis - The blood sample is processed in a laboratory where the levels of protoporphyrin in the red blood cells are measured. This may involve specific biochemical assays designed to quantify protoporphyrin concentrations accurately.
  • Result Interpretation - Once the analysis is complete, the results are interpreted by a qualified healthcare professional. Elevated levels of protoporphyrin are assessed in the context of the patient's clinical history and other laboratory findings to determine the underlying cause.

3. Post-Procedure

After the procedure associated with CPT® Code 84203, there are generally no specific post-procedure care requirements for the patient, as the blood draw is a routine procedure. Patients may experience minor discomfort or bruising at the site of the venipuncture, which typically resolves quickly. The healthcare provider will review the test results with the patient, discussing any necessary follow-up actions or additional testing that may be required based on the findings. It is important for patients to report any unusual symptoms or concerns following the blood draw to their healthcare provider.

Short Descr TEST RBC PROTOPORPHYRIN
Medium Descr PROTOPORPHYRIN RBC SCREEN
Long Descr Protoporphyrin, RBC; screen
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 1
CCS Clinical Classification 233 - Laboratory - Chemistry and Hematology
Date
Action
Notes
Pre-1990 Added Code added.
Code
Description
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