CPT® Code 84403

The CPT® Code 84403 refers to the laboratory test for measuring total testosterone levels in the blood. Testosterone is a crucial androgen hormone produced primarily in the testes of males, the ovaries of females, and the adrenal glands in both sexes. This hormone plays a significant role in various physiological processes, including the promotion of protein synthesis and the support of cell and tissue growth. The measurement of total testosterone is essential for evaluating hormonal balance and diagnosing conditions related to testosterone deficiency or excess. The test can be performed alongside other assessments, such as the measurement of sex hormone binding globulin (SHBG), which is reported under CPT® Code 84270. To obtain the necessary sample for this test, a blood draw is conducted, which is typically reported separately as a venipuncture procedure. The analysis of serum or plasma testosterone levels in adult males is commonly performed using quantitative electrochemiluminescent immunoassay techniques, where the results are calculated based on a mathematical expression that incorporates SHBG levels. For adult females and children, the testing is conducted using advanced methods such as quantitative high-performance liquid chromatography-tandem mass spectrometry or electrochemiluminescent immunoassay, with results similarly derived from SHBG calculations. This comprehensive approach ensures accurate assessment of testosterone levels, aiding in the diagnosis and management of various endocrine disorders.