CPT® Code 84488

The CPT® Code 84488 refers to a qualitative test for trypsin in feces. This test is designed to measure the levels of fecal trypsin, which is an enzyme produced by the pancreas. Trypsin is initially synthesized as an inactive form known as trypsinogen. This inactive zymogen is secreted into the duodenum through the pancreatic duct, where it is activated by the enzyme enteropeptidase into its active form, trypsin. The primary function of trypsin is to hydrolyze ingested proteins into smaller peptides and amino acids, facilitating their absorption and digestion in the gastrointestinal tract. The measurement of fecal trypsin levels is particularly significant in assessing exocrine pancreatic function. A decrease in trypsin levels in stool samples can indicate insufficient production by the pancreas, which is often associated with conditions such as chronic pancreatitis. In addition to its role in diagnosing pancreatic insufficiency, this test is also utilized as a screening tool for cystic fibrosis in symptomatic newborns and infants. In cystic fibrosis, thick mucus can obstruct the pancreatic ducts, preventing the proper flow of trypsinogen into the small intestine, leading to reduced trypsin levels in feces. It is important to note that for a quantitative assessment of fecal trypsin, CPT® Code 84490 should be used instead.