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Official Description

Urobilinogen, urine; semiquantitative

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

Urobilinogen is a biochemical compound that results from the reduction of bilirubin, a substance produced during the breakdown of red blood cells. This reduction process primarily occurs in the intestine, where bilirubin is converted into urobilinogen. A small portion of urobilinogen is then reabsorbed from the intestine into the bloodstream and subsequently filtered by the kidneys, which is part of the enterohepatic urobilinogen cycle. The measurement of urobilinogen in urine can provide valuable insights into various health conditions. Elevated levels of urobilinogen in urine may indicate several medical issues, including biliary obstruction, hepatic infections, poisoning, or inflammation, as well as hemolytic anemia. Additionally, elevated levels can occur when the body is absorbing a large hematoma. Conversely, decreased levels of urobilinogen may be observed in cases of congenital enzymatic jaundice or when urine acidifying drugs are present. For different types of evaluations, specific CPT codes are utilized: CPT® Code 84578 is designated for qualitative evaluation, CPT® Code 84580 is used for quantitative, timed specimen evaluations, and CPT® Code 84583 is specifically for semiquantitative evaluations of urobilinogen in urine.

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