CPT® Code 85415

The CPT® Code 85415 refers to a laboratory test that measures fibrinolytic factors and inhibitors, specifically focusing on plasminogen activator. This test evaluates the activity of plasminogen activator inhibitor type I (PAI-I), which is a serine protease inhibitor produced primarily by endothelial cells and adipose tissue, as well as by the placenta (referred to as PAI-2). The role of plasminogen activator is crucial in the regulation of fibrinolysis, a process that prevents blood clots from growing and becoming problematic. It specifically targets tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA) to modulate this process. A deficiency in PAI-I, which can be inherited, may lead to delayed mild to moderate bleeding, particularly after trauma or surgical procedures. Conversely, elevated levels of PAI-I can be indicative of various health conditions, including certain types of cancers such as breast, gastric, lung, and cervical cancers, as well as obesity, metabolic syndrome, and inflammatory disorders. The test is performed on a blood sample that is obtained through a separately reportable venipuncture. The analysis involves testing platelet-poor plasma for PAI-I activity using a bioimmunoassay and measuring tissue plasminogen activator antigen through an enzyme-linked immunosorbent assay (ELISA).