CPT® Code 85597

The CPT® Code 85597 refers to a specific laboratory test known as phospholipid neutralization, which is commonly associated with the detection of lupus anticoagulants (LA). This test is also referred to as an anti-phospholipid antibody test. Lupus anticoagulants are a diverse group of antibodies that target phospholipid-protein complexes within the body. The presence of these antibodies in the bloodstream can lead to an extended clotting time, which is a critical factor in assessing coagulation disorders. The test operates on the principle that when lysed platelet phospholipid is introduced into a sample containing lupus anticoagulants, these antibodies are neutralized, resulting in a shortened clotting time. The methodology employed in this test involves photo-optical clot detection, which allows for precise measurement of clotting times. By comparing the clotting time of the sample with and without the addition of lysed platelet phospholipid, healthcare professionals can determine the presence of lupus anticoagulants. An increased clotting time in the absence of lysed platelet phospholipid indicates a positive result for LA. While a positive test result may suggest the presence of systemic lupus erythematosus (SLE), it is important to note that most individuals who test positive for lupus anticoagulants do not have SLE. This test is frequently utilized to investigate the underlying causes of unexplained thrombosis, recurrent fetal loss, thrombocytopenia, or prolonged partial thromboplastin time (PTT) tests, making it a valuable tool in the diagnostic process for various hematological conditions.