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Official Description

C-reactive protein; high sensitivity (hsCRP)

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 86141 refers to the high sensitivity C-reactive protein (hsCRP) test, which is a specific blood test designed to measure the levels of hsCRP in the bloodstream. This test is particularly significant as it focuses on a narrow range of low concentrations of C-reactive protein, which is crucial for assessing the risk of various cardiovascular conditions. Elevated hsCRP levels can indicate an increased risk for cardiovascular disease, stroke, myocardial infarction, and peripheral vascular disease, especially in individuals who are otherwise healthy. C-reactive protein is classified as an acute phase protein, which means it is produced by the liver and released into the bloodstream in response to inflammation and infection. The hsCRP test is valuable in clinical settings as it helps healthcare providers evaluate inflammation levels that may not be apparent through other means. It is important to note that certain factors can influence hsCRP levels; for instance, the use of nonsteroidal anti-inflammatory drugs (NSAIDs) and statins may lead to decreased levels, while illness, tissue injury, infectious diseases, inflammatory conditions, or hormone replacement therapy can result in increased levels. Typically, this test is ordered alongside a lipid panel or other cardiac risk assessment tests to provide a comprehensive evaluation of a patient's cardiovascular health. The blood sample required for this test is obtained through a venipuncture, which is a separately reportable procedure, and the serum or plasma is analyzed using a quantitative immunoturbidimetric method to determine the hsCRP concentration.

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