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Official Description

Cardiolipin (phospholipid) antibody, each Ig class

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 86147 refers to the laboratory test for cardiolipin (phospholipid) antibodies, specifically measuring each immunoglobulin (Ig) class, which includes IgA, IgG, and IgM. This test is conducted on a blood sample to identify the presence of these antibodies, which are associated with various medical conditions. The presence of cardiolipin antibodies is particularly significant in patients who have experienced unexplained venous or arterial thrombosis, thrombocytopenia (a condition characterized by low platelet counts), or fetal losses. The testing process typically involves an initial assessment, and if cardiolipin antibodies are detected, it is common practice to repeat the test approximately six weeks later. This follow-up is crucial to ascertain whether the antibodies are persistently present or merely a temporary finding, as low to moderate levels can sometimes occur due to infections or the influence of certain medications. In contrast, consistently elevated levels of these antibodies may suggest a more serious underlying issue, potentially contributing to the aforementioned conditions. Each class of cardiolipin antibody is reported separately, allowing for a detailed analysis of the patient's immune response.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The cardiolipin antibody test (CPT® Code 86147) is indicated for patients presenting with specific clinical conditions that may warrant further investigation into the presence of these antibodies. The following indications are explicitly recognized for this procedure:

  • Unexplained Venous Thrombosis - Patients who have experienced blood clots in the veins without an identifiable cause may be tested for cardiolipin antibodies to assess potential underlying factors.
  • Unexplained Arterial Thrombosis - Similar to venous thrombosis, arterial blood clots that occur without a clear reason can lead to testing for these antibodies to evaluate the risk of further thrombotic events.
  • Thrombocytopenia - Individuals with low platelet counts may undergo this test to determine if cardiolipin antibodies are contributing to their condition.
  • Fetal Losses - Women who have experienced recurrent fetal losses may be tested for cardiolipin antibodies to investigate potential autoimmune factors that could be affecting pregnancy outcomes.

2. Procedure

The procedure for testing cardiolipin antibodies involves several key steps, which are outlined as follows:

  • Step 1: Blood Sample Collection - A healthcare professional will collect a blood sample from the patient, typically via venipuncture. This sample is essential for the subsequent laboratory analysis of cardiolipin antibodies.
  • Step 2: Laboratory Analysis - The collected blood sample is sent to a laboratory where it undergoes testing to detect the presence of cardiolipin antibodies. The analysis is performed for each immunoglobulin class: IgA, IgG, and IgM, with results reported separately for each class.
  • Step 3: Interpretation of Results - Once the laboratory analysis is complete, the results are interpreted by a qualified healthcare provider. If one or more classes of cardiolipin antibodies are detected, the provider may recommend a follow-up test approximately six weeks later to assess the persistence of the antibodies.

3. Post-Procedure

After the cardiolipin antibody test is performed, patients may not require any specific post-procedure care. However, it is important for healthcare providers to communicate the results to the patient and discuss any necessary follow-up actions. If cardiolipin antibodies are detected, the provider may schedule a repeat test in about six weeks to determine if the antibodies are persistent. Patients should be informed about the potential implications of the test results, including the need for further evaluation or management of any underlying conditions related to thrombosis, thrombocytopenia, or fetal losses.

Short Descr CARDIOLIPIN ANTIBODY EA IG
Medium Descr CARDIOLIPIN ANTIBODY EACH IG CLASS
Long Descr Cardiolipin (phospholipid) antibody, each Ig class
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 4
CCS Clinical Classification 235 - Other Laboratory
90 Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number.
91 Repeat clinical diagnostic laboratory test: in the course of treatment of the patient, it may be necessary to repeat the same laboratory test on the same day to obtain subsequent (multiple) test results. under these circumstances, the laboratory test performed can be identified by its usual procedure number and the addition of modifier 91. note: this modifier may not be used when tests are rerun to confirm initial results; due to testing problems with specimens or equipment; or for any other reason when a normal, one-time, reportable result is all that is required. this modifier may not be used when other code(s) describe a series of test results (eg, glucose tolerance tests, evocative/suppression testing). this modifier may only be used for laboratory test(s) performed more than once on the same day on the same patient.
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
Q1 Routine clinical service provided in a clinical research study that is in an approved clinical research study
26 Professional component: certain procedures are a combination of a physician or other qualified health care professional component and a technical component. when the physician or other qualified health care professional component is reported separately, the service may be identified by adding modifier 26 to the usual procedure number.
77 Repeat procedure by another physician or other qualified health care professional: it may be necessary to indicate that a basic procedure or service was repeated by another physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 77 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
GA Waiver of liability statement issued as required by payer policy, individual case
32 Mandated services: services related to mandated consultation and/or related services (eg, third party payer, governmental, legislative or regulatory requirement) may be identified by adding modifier 32 to the basic procedure.
CC Procedure code change (use 'cc' when the procedure code submitted was changed either for administrative reasons or because an incorrect code was filed)
GW Service not related to the hospice patient's terminal condition
GY Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit
GZ Item or service expected to be denied as not reasonable and necessary
X3 Episodic/broad services: for reporting services by clinicians who have broad responsibility for the comprehensive needs of the patient that is limited to a defined period and circumstance such as a hospitalization; reporting clinician service examples include but are not limited to the hospitalist's services rendered providing comprehensive and general care to a patient while admitted to the hospital
XE Separate encounter, a service that is distinct because it occurred during a separate encounter
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
Date
Action
Notes
2013-01-01 Changed Short Descriptor changed.
2001-01-01 Changed Code description changed.
1993-01-01 Added First appearance in code book in 1993.
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