CPT® Code 86225

The CPT® Code 86225 refers to a laboratory test that measures the presence of native or double-stranded deoxyribonucleic acid (DNA) antibodies, specifically the IgG type. This test is significant in the context of autoimmune disorders, particularly systemic lupus erythematosus (SLE), a condition characterized by the immune system attacking its own tissues. The detection of DNA antibodies is often utilized as a secondary screening tool for SLE, especially when initial tests for anti-nuclear antibodies yield positive results. Furthermore, this test can be instrumental in monitoring the disease activity in patients who have already been diagnosed with SLE. It is important to note that there are two types of tests for DNA antibodies: the high avidity test and the low affinity test. The high avidity test is particularly specific for SLE cases that involve renal complications, known as lupus nephritis, although it is less sensitive in detecting DNA antibodies compared to the low affinity test. To perform this test, a blood sample is collected through venipuncture, which is a separately reportable procedure. The serum obtained from the blood sample is then analyzed using a qualitative enzyme-linked immunosorbent assay (ELISA), a common laboratory technique used to detect and quantify proteins, antibodies, and hormones in a sample.