CPT® Code 86309

The CPT® Code 86309 refers to the laboratory test that measures the titer of heterophile antibodies in a blood sample. Heterophile antibodies are typically associated with the Epstein-Barr virus (EBV), which is known to cause infectious mononucleosis (IM). This test is crucial for diagnosing IM, particularly when a patient presents with symptoms such as fever, headache, sore throat, swollen lymph nodes, fatigue, and abdominal discomfort. The presence of these antibodies indicates an immune response to the EBV infection. It is important to note that the test may yield negative results during the early stages of the infection, necessitating a repeat test if symptoms continue. Additionally, infants and young children may not produce heterophile antibodies, resulting in negative test outcomes despite having an EBV infection. The blood sample for this test is collected through venipuncture, and the analysis is performed using a semiquantitative latex agglutination method. When the initial screening test for heterophile antibodies is positive, the titer measurement is reported using CPT® Code 86309, providing further insight into the level of antibodies present in the patient's serum or plasma.