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Immunoelectrophoresis is a laboratory technique utilized to separate and characterize proteins based on their specific interactions with antibodies. This method is particularly valuable in the analysis of various body fluids, allowing for the identification and quantification of immunoglobulins, which are proteins that function as antibodies. The procedure can be performed using different methodologies, including one-dimensional and two-dimensional techniques, each designed to enhance the resolution and specificity of protein separation. While the serum test, identified by CPT® Code 86320, is commonly employed to evaluate levels of abnormal immunoglobulins associated with conditions such as multiple myeloma, chronic lymphocytic leukemia, Waldenstrom macroglobulinemia, amyloidosis, and lymphoma, CPT® Code 86325 specifically pertains to immunoelectrophoresis conducted on other bodily fluids. These fluids may include cerebrospinal fluid, synovial fluid, and urine, providing critical insights into various pathological conditions. The use of immunoelectrophoresis has been somewhat supplanted by the immunofixation method, which offers enhanced specificity in identifying monoclonal immunoglobulins. However, CPT® Code 86325 remains relevant for cases where analysis of non-serum fluids is necessary for diagnostic purposes.
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Immunoelectrophoresis is indicated for the analysis of various body fluids to detect and characterize abnormal immunoglobulins. The following conditions may warrant the use of this procedure:
The procedure for immunoelectrophoresis on other fluids involves several key steps to ensure accurate separation and characterization of proteins:
After the immunoelectrophoresis procedure, the results are analyzed and interpreted by a qualified laboratory professional. The expected recovery for the patient is typically immediate, as the procedure is minimally invasive and does not require extensive recovery time. However, the interpretation of results may require additional clinical correlation and follow-up testing to confirm any findings. It is essential to document the results accurately and communicate them to the referring physician for further evaluation and management of the patient's condition.
| Short Descr | OTHER IMMUNOELECTROPHORESIS | Medium Descr | IMMUNOELECTROPHORESIS OTHER FLUIDS CONCENTRATION | Long Descr | Immunoelectrophoresis; other fluids (eg, urine, cerebrospinal fluid) with concentration | Status Code | Active Code | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 6 - Laboratory Physician Interpretation Code | Multiple Procedures (51) | 0 - No payment adjustment rules for multiple procedures apply. | Bilateral Surgery (50) | 0 - 150% payment adjustment for bilateral procedures does NOT apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 0 - Payment restriction for assistants at surgery applies to this procedure... | Co-Surgeons (62) | 0 - Co-surgeons not permitted for this procedure. | Team Surgery (66) | 0 - Team surgeons not permitted for this procedure. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 2 | CCS Clinical Classification | 235 - Other Laboratory |
| 26 | Professional component: certain procedures are a combination of a physician or other qualified health care professional component and a technical component. when the physician or other qualified health care professional component is reported separately, the service may be identified by adding modifier 26 to the usual procedure number. | GC | This service has been performed in part by a resident under the direction of a teaching physician | 59 | Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25. | 90 | Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number. | 91 | Repeat clinical diagnostic laboratory test: in the course of treatment of the patient, it may be necessary to repeat the same laboratory test on the same day to obtain subsequent (multiple) test results. under these circumstances, the laboratory test performed can be identified by its usual procedure number and the addition of modifier 91. note: this modifier may not be used when tests are rerun to confirm initial results; due to testing problems with specimens or equipment; or for any other reason when a normal, one-time, reportable result is all that is required. this modifier may not be used when other code(s) describe a series of test results (eg, glucose tolerance tests, evocative/suppression testing). this modifier may only be used for laboratory test(s) performed more than once on the same day on the same patient. | CC | Procedure code change (use 'cc' when the procedure code submitted was changed either for administrative reasons or because an incorrect code was filed) | GA | Waiver of liability statement issued as required by payer policy, individual case | GV | Attending physician not employed or paid under arrangement by the patient's hospice provider | GW | Service not related to the hospice patient's terminal condition | Q1 | Routine clinical service provided in a clinical research study that is in an approved clinical research study | XU | Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service |
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| 2002-01-01 | Changed | Code description changed. |
| Pre-1990 | Added | Code added. |
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