CPT® Code 86408

The CPT® Code 86408 refers to a screening test for neutralizing antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease (COVID-19). This test is primarily utilized to assess the presence and functionality of antibodies in individuals who have recovered from COVID-19 or have been vaccinated against it. The neutralizing antibody screening is crucial for determining the eligibility of plasma donors who have convalesced from COVID-19, as their plasma may contain antibodies that can be beneficial for treating patients currently infected with the virus. Additionally, this test helps evaluate an individual's immune response to SARS-CoV-2, providing insights into whether they possess adequate protection against potential infection or reinfection. The methodology involves assessing how effectively the antibodies present in the serum or plasma can inhibit viral growth in vitro, which is indicative of their neutralizing capability. By monitoring viral growth inhibition in a controlled cell culture environment, healthcare professionals can gain valuable information regarding the immune status of the individual being tested.