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Official Description

Skin test; unlisted antigen, each

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

A skin test for an unlisted antigen, as described by CPT® Code 86486, involves the introduction of a specific antigen into the skin to evaluate the immune response of an individual. An antigen is defined as a substance that can provoke an immune response, particularly in individuals who have previously been sensitized to it. In this procedure, the unlisted antigen is injected just beneath the skin's surface, leading to the formation of a localized reaction known as a wheal. This wheal appears as a discrete, pale elevation on the skin and is typically absorbed quickly. The significance of this test lies in its ability to determine whether the individual has antibodies against the introduced antigen. If antibodies are present, the individual may experience localized swelling and/or itching at the injection site. The evaluation of the test's outcome occurs 48 to 72 hours post-injection, during which the healthcare provider assesses the injection site for any raised or hardened areas. The extent of the reaction is meticulously measured and documented, providing critical information regarding the individual's sensitivity to the antigen in question.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The skin test for an unlisted antigen (CPT® Code 86486) is indicated for various clinical scenarios where specific antigen sensitivity needs to be assessed. The following conditions may warrant the use of this test:

  • Allergic Reactions The test may be performed to evaluate potential allergic reactions to substances that do not have a specific skin test code.
  • Immune Response Assessment It is utilized to determine the immune response of an individual to an unlisted antigen, particularly in cases where previous exposure is suspected.
  • Diagnostic Clarification The procedure can help clarify diagnoses related to hypersensitivity or immune disorders when standard tests are not applicable.

2. Procedure

The procedure for conducting a skin test for an unlisted antigen involves several key steps that ensure accurate assessment of the immune response. The following procedural steps are outlined:

  • Step 1: Preparation The healthcare provider prepares the testing area by cleaning the skin at the site of injection to minimize the risk of infection and ensure accurate results.
  • Step 2: Antigen Injection The unlisted antigen is then introduced just beneath the skin's surface using a syringe. This injection is performed with precision to create a localized reaction.
  • Step 3: Observation of Reaction After the injection, the site is monitored for the development of a wheal, which is a pale elevation of the skin. This reaction indicates the body's response to the antigen.
  • Step 4: Reading the Test The test site is evaluated 48 to 72 hours post-injection. The healthcare provider checks for any raised or hardened areas at the injection site, which may indicate a positive reaction.
  • Step 5: Documentation Finally, the extent of any reaction is measured and recorded in the patient's medical record, providing essential information for further clinical decision-making.

3. Post-Procedure

Post-procedure care following the skin test for an unlisted antigen involves monitoring the injection site for any delayed reactions. Patients may be advised to avoid scratching or irritating the area to prevent complications. The healthcare provider will review the results with the patient, discussing any reactions observed and their implications for future exposure to the antigen. Additionally, if significant swelling or discomfort occurs, further evaluation may be warranted to address any potential allergic reactions. Documentation of the test results is crucial for ongoing patient management and future reference.

Short Descr SKIN TEST UNLISTED ANTIGN EA
Medium Descr SKIN TEST UNLISTED ANTIGEN EACH
Long Descr Skin test; unlisted antigen, each
Status Code Active Code
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 3 - Technical Component Only Code
Multiple Procedures (51) 0 - No payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 0 - Payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator STV-Packaged Codes
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 2
CCS Clinical Classification 235 - Other Laboratory
Date
Action
Notes
2023-01-01 Note Short description changed.
2011-01-01 Changed Short description changed.
2008-01-01 Added First appearance in code book in 2008.
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