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Official Description

Antibody; Helicobacter pylori

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 86677 refers to a laboratory test specifically designed to measure antibodies against Helicobacter pylori (H. pylori). H. pylori is a type of bacterium that can be found in contaminated food and water and has the potential to spread from person to person. This organism is known to cause chronic inflammation of the gastrointestinal mucosa, particularly affecting the stomach and duodenum, which can lead to the development of erosions or ulcers in these areas. The test measures the seroconversion of immunoglobulin A (IgA) and immunoglobulin G (IgG) antibodies, which typically occurs within approximately 60 days following exposure to the bacterium. Elevated levels of both IgA and IgG antibodies, especially when accompanied by gastrointestinal symptoms, may indicate an active H. pylori infection. It is important to note that while the antibody test can provide valuable information, it should be confirmed through additional diagnostic methods such as bacterial isolation, H. pylori breath tests, or fecal antigen tests using enzyme immunoassay (EIA). Although testing for IgM antibodies is also possible, the clinical significance of this measurement remains uncertain. The test requires a blood sample, which is obtained through a venipuncture that is reported separately. The serum is then analyzed for IgA and IgG antibodies using a semi-quantitative enzyme immunoassay, while IgM antibodies are assessed using a semi-quantitative enzyme-linked immunosorbent assay (ELISA).

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The antibody test for Helicobacter pylori (CPT® Code 86677) is indicated for the following conditions:

  • Chronic gastrointestinal symptoms Patients presenting with ongoing gastrointestinal issues such as abdominal pain, bloating, or nausea may require testing to determine if H. pylori infection is a contributing factor.
  • Diagnosis of peptic ulcers The test is utilized in the evaluation of patients suspected of having peptic ulcers, as H. pylori is a known causative agent of ulcer formation.
  • Monitoring treatment efficacy Following treatment for H. pylori infection, this test can be used to assess the effectiveness of the therapy by measuring antibody levels.

2. Procedure

The procedure for conducting the H. pylori antibody test involves several key steps:

  • Step 1: Patient preparation Prior to the test, the patient may be instructed to avoid certain medications or foods that could interfere with the results. It is essential to ensure that the patient is adequately informed about the procedure and any necessary preparations.
  • Step 2: Venipuncture A qualified healthcare professional performs a venipuncture to obtain a blood sample from the patient. This step is crucial as the serum obtained from the blood will be used for the antibody testing. The venipuncture site is typically cleaned with an antiseptic to minimize the risk of infection.
  • Step 3: Serum separation After the blood sample is collected, it is processed to separate the serum from the cellular components. This is typically done by centrifugation, which allows for the clear serum to be isolated for testing.
  • Step 4: Antibody testing The serum is then subjected to testing for IgA and IgG antibodies using a semi-quantitative enzyme immunoassay. If IgM antibodies are also tested, a semi-quantitative enzyme-linked immunosorbent assay (ELISA) is employed. These assays measure the levels of antibodies present in the serum, providing insight into the patient's immune response to H. pylori.

3. Post-Procedure

After the procedure, the patient may experience minimal discomfort at the venipuncture site, which typically resolves quickly. There are no specific post-procedure care instructions required for this test, as it is a routine laboratory procedure. The results of the antibody test will be interpreted by the healthcare provider, who will discuss the findings with the patient and determine if further diagnostic testing or treatment is necessary based on the results. It is important for the patient to follow up with their healthcare provider to understand the implications of the test results and any subsequent steps that may be required.

Short Descr HELICOBACTER PYLORI ANTIBODY
Medium Descr ANTIBODY HELICOBACTER PYLORI
Long Descr Antibody; Helicobacter pylori
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 3
CCS Clinical Classification 235 - Other Laboratory
90 Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number.
91 Repeat clinical diagnostic laboratory test: in the course of treatment of the patient, it may be necessary to repeat the same laboratory test on the same day to obtain subsequent (multiple) test results. under these circumstances, the laboratory test performed can be identified by its usual procedure number and the addition of modifier 91. note: this modifier may not be used when tests are rerun to confirm initial results; due to testing problems with specimens or equipment; or for any other reason when a normal, one-time, reportable result is all that is required. this modifier may not be used when other code(s) describe a series of test results (eg, glucose tolerance tests, evocative/suppression testing). this modifier may only be used for laboratory test(s) performed more than once on the same day on the same patient.
GV Attending physician not employed or paid under arrangement by the patient's hospice provider
GW Service not related to the hospice patient's terminal condition
GA Waiver of liability statement issued as required by payer policy, individual case
77 Repeat procedure by another physician or other qualified health care professional: it may be necessary to indicate that a basic procedure or service was repeated by another physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 77 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
Q4 Service for ordering/referring physician qualifies as a service exemption
26 Professional component: certain procedures are a combination of a physician or other qualified health care professional component and a technical component. when the physician or other qualified health care professional component is reported separately, the service may be identified by adding modifier 26 to the usual procedure number.
GC This service has been performed in part by a resident under the direction of a teaching physician
GY Item or service statutorily excluded, does not meet the definition of any medicare benefit or, for non-medicare insurers, is not a contract benefit
GZ Item or service expected to be denied as not reasonable and necessary
QW Clia waived test
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
Date
Action
Notes
2013-01-01 Changed Short Descriptor changed.
2001-01-01 Changed Code description changed.
1993-01-01 Added First appearance in code book in 1993.
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