CPT® Code 86817

Human leukocyte antigen (HLA) typing is a laboratory procedure that identifies specific antigens present on the surface of white blood cells, which are crucial for the immune system's ability to recognize foreign substances. The procedure focuses on the DR and DQ antigens, which are part of the Class II HLA system. HLA typing is essential for determining tissue compatibility between potential organ or stem cell donors and recipients, thereby reducing the risk of transplant rejection. Additionally, HLA typing can identify individuals who may be genetically predisposed to certain diseases. For instance, specific HLA alleles such as HLA-DQ2 and HLA-DQ8 are associated with celiac disease, particularly in patients who exhibit symptoms or have a family history of the condition. Furthermore, HLA-DR15 and HLA-DQ6 typing can assist in distinguishing narcolepsy from other sleep disorders. The procedure can also be utilized to assess susceptibility to various autoimmune disorders. It is important to note that when testing for a single antigen, the appropriate code to use is 86816, while 86817 is designated for cases where multiple HLA antigens are typed.