CPT® Code 86922

The CPT® Code 86922 refers to a compatibility test performed using the antiglobulin technique to assess the compatibility between a unit of blood and a recipient. This laboratory test is crucial in ensuring that the blood transfusion process is safe and effective, as it helps to prevent adverse reactions that can occur when incompatible blood types are mixed. Compatibility testing, often known as cross-matching (CM), is a vital step in the transfusion process. The antiglobulin technique is specifically employed when there is a positive result from a patient’s antibody screening test or if there is a documented history of clinically significant antibodies that could lead to complications, such as acute hemolytic transfusion reactions. The procedure involves the use of monoclonal antibodies, known as Coombs reagent, which target immunoglobulin G (IgG) and complement component 3 (C3). This allows for the detection of non-agglutinating red cell antibodies through an indirect antiglobulin test (IAT) or sensitized red cells through a direct antiglobulin test (DAT). The test is performed by mixing the patient’s red blood cells with the reagent and observing for agglutination, which indicates a reaction. The antiglobulin technique is essential for identifying potential incompatibilities that may not be detected by simpler methods, thereby enhancing patient safety during blood transfusions.