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Official Description

Leukocyte transfusion

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

Leukocyte transfusion, represented by CPT® Code 86950, involves the infusion of white blood cells into a patient. This procedure is typically performed on individuals who are experiencing a significant reduction in their white blood cell count, often due to conditions such as infections or other diseases that compromise the immune system. White blood cells, or leukocytes, play a crucial role in the body's defense against infections and are essential for maintaining a healthy immune response. The transfusion aims to restore the patient's ability to fight off infections and improve overall health by increasing the number of circulating leukocytes. This procedure is particularly important in patients who are immunocompromised or have undergone treatments that adversely affect their white blood cell production, such as chemotherapy or radiation therapy.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

Leukocyte transfusion is indicated for patients who are experiencing a significant decrease in white blood cell levels due to various medical conditions. The following are specific indications for this procedure:

  • Infection Patients suffering from severe infections that require an enhanced immune response may benefit from leukocyte transfusion to help combat the infection.
  • Bone Marrow Disorders Conditions affecting the bone marrow, such as aplastic anemia or leukemia, can lead to low white blood cell counts, making transfusion necessary.
  • Post-Chemotherapy Individuals who have undergone chemotherapy may experience a drop in white blood cell production, necessitating a transfusion to restore immune function.

2. Procedure

The leukocyte transfusion procedure involves several critical steps to ensure the safe and effective administration of white blood cells. The following outlines the procedural steps:

  • Step 1: Patient Assessment Prior to the transfusion, a thorough assessment of the patient is conducted. This includes reviewing the patient's medical history, current health status, and specific indications for the transfusion. Blood tests may be performed to confirm low white blood cell counts and to ensure compatibility with the donor leukocytes.
  • Step 2: Preparation of Leukocyte Product The leukocyte product is prepared from a donor's blood, which is collected and processed to isolate the white blood cells. This may involve centrifugation and other laboratory techniques to ensure that the leukocytes are concentrated and free from contaminants.
  • Step 3: Administration of Transfusion The leukocyte transfusion is administered intravenously, typically through a standard blood transfusion setup. The healthcare provider closely monitors the patient during the transfusion for any adverse reactions, ensuring that the infusion rate is appropriate and that the patient remains stable throughout the procedure.
  • Step 4: Post-Transfusion Monitoring After the transfusion is completed, the patient is monitored for a period to assess for any immediate reactions or complications. Vital signs are checked, and the patient's response to the transfusion is evaluated to ensure that the desired therapeutic effect is achieved.

3. Post-Procedure

Following a leukocyte transfusion, patients are typically monitored for any potential side effects or adverse reactions, which may include fever, chills, or allergic reactions. It is essential to observe the patient for signs of improvement in their white blood cell count and overall immune function. Additional blood tests may be conducted to evaluate the effectiveness of the transfusion. Patients may also receive instructions regarding any necessary follow-up care or additional treatments that may be required based on their underlying condition. Overall, the goal of post-procedure care is to ensure the patient's safety and to support their recovery process.

Short Descr LEUKACYTE TRANSFUSION
Medium Descr LEUKOCYTE TRANSFUSION
Long Descr Leukocyte transfusion
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator STV-Packaged Codes
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 1
CCS Clinical Classification 235 - Other Laboratory
Date
Action
Notes
2013-01-01 Changed Guideline information changed.
1993-01-01 Added First appearance in code book in 1993.
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