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The CPT® Code 87301 refers to a laboratory test designed to detect the presence of adenovirus enteric types 40 and 41 antigens in a sample using various immunoassay techniques. These adenovirus types are significant pathogens known to cause acute gastroenteritis, particularly in infants and children, and are recognized as leading causes of this condition, following rotavirus and norovirus. The symptoms associated with adenovirus infections typically include diarrhea, abdominal pain, fever, and vomiting, which can persist for approximately 10 days. While the illness is generally self-limiting in healthy individuals, it poses a higher risk of severe outcomes in immunocompromised patients. To perform this test, a fecal sample is collected, which may be preserved in a fixative or sent fresh to the laboratory for analysis. The detection methods employed in this test include enzyme immunoassay (EIA), enzyme-linked immunosorbent assay (ELISA), fluorescence immunoassay (FIA), and immunochemiluminometric assay (IMCA). Each of these techniques operates on the principle of binding the adenovirus antigen to a specific antibody, followed by the addition of a secondary antibody that is enzyme-labeled or fluorescent. The resulting reactions produce measurable signals, such as color changes or fluorescence, which indicate the presence of the antigen. The test results can be reported as qualitative, indicating the presence or absence of the antigen, or semi-quantitative, providing an estimate of the antigen concentration based on colorimetric readings or fluorescence intensity.
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The CPT® Code 87301 is indicated for the detection of adenovirus enteric types 40 and 41 in patients presenting with symptoms of acute gastroenteritis. The following conditions warrant the use of this test:
The procedure for conducting the test under CPT® Code 87301 involves several key steps to ensure accurate detection of the adenovirus antigen:
After the completion of the test, the laboratory will analyze the results and report them to the requesting healthcare provider. It is essential for the provider to interpret the results in the context of the patient's clinical presentation and history. Follow-up care may be necessary, especially for immunocompromised patients, to monitor for potential complications or the need for further medical intervention. Additionally, healthcare providers should ensure that patients are informed about the nature of the test results and any subsequent steps that may be required based on the findings.
| Short Descr | ADENOVIRUS AG IA | Medium Descr | IAAD IA ADENOVIRUS ENTERIC TYP 40/41 | Long Descr | Infectious agent antigen detection by immunoassay technique (eg, enzyme immunoassay [EIA], enzyme-linked immunosorbent assay [ELISA], fluorescence immunoassay [FIA], immunochemiluminometric assay [IMCA]), qualitative or semiquantitative; adenovirus enteric types 40/41 | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 1 | CCS Clinical Classification | 206 - Microscopic examination (bacterial smear, culture, toxicology) |
| 90 | Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number. | CS | Cost-sharing waived for specified covid-19 testing-related services that result in and order for or administration of a covid-19 test and/or used for cost-sharing waived preventive services furnished via telehealth in rural health clinics and federally qualified health centers during the covid-19 public health emergency |
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| 2022-01-01 | Changed | First appearance of change in codebook. |
| 2022-01-01 | Note | Grammatical correction. |
| 2021-01-01 | Changed | First appearance of change in CPT® Code Set. |
| 2020-10-06 | Changed | Code changed. |
| 2016-01-01 | Changed | Description Changed |
| 2011-01-01 | Changed | Short description changed. |
| 2007-01-01 | Changed | Code description changed. |
| 1998-01-01 | Added | First appearance in code book in 1998. |
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