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The CPT® Code 87523 refers to a laboratory test designed for the detection and quantification of the hepatitis D (delta) virus, utilizing nucleic acid techniques. This procedure specifically targets the presence of the hepatitis D virus (HDV) in serum or plasma samples through a method known as real-time polymerase chain reaction (RT-PCR). Hepatitis D is a unique viral infection that can only occur in individuals who are also infected with the hepatitis B virus (HBV), as it relies on HBV for its replication. The hepatitis D virus is classified as a mutated RNA virus and is distinct from other hepatitis viruses such as A, B, and C. The presence of HDV can lead to severe liver complications, particularly in patients with existing hepatitis B infections, potentially resulting in conditions such as fulminant acute hepatitis, cirrhosis, and hepatocellular carcinoma. The testing process involves treating the viral RNA to protect it from degradation, followed by reverse transcription, which converts the RNA into complementary DNA (cDNA). This cDNA is then amplified using specific primers that bind to the target nucleic acid, allowing for the measurement of fluorescence at each cycle of the PCR process. The quantification of the generated DNA is crucial for monitoring the progression of the disease and assessing the patient's response to treatment.
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The CPT® Code 87523 is indicated for the detection and quantification of the hepatitis D (delta) virus in patients who are known to be infected with the hepatitis B virus. The following conditions may warrant the use of this test:
The procedure for CPT® Code 87523 involves several critical steps to ensure accurate detection and quantification of the hepatitis D virus. The following outlines the procedural steps:
After the completion of the procedure associated with CPT® Code 87523, the laboratory will analyze the results and provide a report detailing the presence and quantity of the hepatitis D virus. Clinicians will use this information to monitor disease progression, evaluate the effectiveness of treatment, and make informed decisions regarding patient management. It is important for healthcare providers to interpret the results in the context of the patient's overall clinical picture, including any co-infections and liver function status. Follow-up testing may be necessary based on the initial findings to ensure ongoing monitoring of the patient's condition.
| Short Descr | HEPATITIS D QUANTIFICATION | Medium Descr | IADNA HEPATITIS D DELTA QUAN W/REV TRANSCRIPTION | Long Descr | Infectious agent detection by nucleic acid (DNA or RNA); hepatitis D (delta), quantification, including reverse transcription, when performed | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | none | MUE | 1 |
| 90 | Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number. |
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| 2024-01-01 | Added | Code Added. |
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