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The CPT® Code 87525 refers to a laboratory test designed for the detection of the hepatitis G virus (HGV), also known as GB virus-C (GBV-C), through the use of nucleic acid techniques, specifically targeting DNA or RNA. This test employs a direct probe technique to identify the unique nucleic acid sequence of the hepatitis G virus present in a blood sample. HGV infections are often asymptomatic and do not typically lead to significant liver inflammation; however, they can occur alongside other viral infections that do cause acute or chronic hepatitis. The transmission of HGV primarily occurs through infected blood and blood products, from mother to infant during childbirth, and through sexual contact with an infected partner. The direct probe test utilizes a labeled probe that binds specifically to the target sequence of the hepatitis G virus, allowing for its detection if present in the sample. The probe is equipped with fluorescent or chemiluminescent labels, enhancing the visibility of the target sequence. The process involves treating the sample to release nucleic acids from the virus, followed by the formation of a stable hybrid between the probe and the target sequence. Ribosomal RNA is often the focus of these tests due to its abundance in microorganisms, which allows for more effective detection compared to genomic DNA. For enhanced sensitivity, an amplified probe technique (CPT® Code 87526) may be employed, which involves exponentially increasing the target sequence of the hepatitis G virus DNA or RNA prior to detection. This amplification is commonly achieved through polymerase chain reaction (PCR) or reverse transcriptase polymerase chain reaction (RT-PCR). Furthermore, nucleic acid detection with quantification (CPT® Code 87527) provides an assessment of the quantity of microorganisms present, utilizing quantitative or real-time PCR to generate detailed reports on the amounts of the detected nucleic acid sequences.
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The CPT® Code 87525 is indicated for the detection of the hepatitis G virus (HGV) in patients who may be at risk for infection. The following conditions and situations warrant the use of this test:
The procedure for CPT® Code 87525 involves several critical steps to ensure accurate detection of the hepatitis G virus. The following outlines the procedural steps:
After the completion of the procedure associated with CPT® Code 87525, the laboratory will analyze the results and generate a report detailing the presence or absence of the hepatitis G virus in the sample. If the virus is detected, further clinical evaluation and management may be necessary, depending on the patient's overall health and any co-existing conditions. It is important for healthcare providers to discuss the results with the patient and consider any implications for treatment or further testing. Additionally, proper documentation of the procedure and results is essential for compliance and billing purposes.
| Short Descr | HEPATITIS G DNA DIR PROBE | Medium Descr | IADNA HEPATITIS G DIRECT PROBE TECHNIQUE | Long Descr | Infectious agent detection by nucleic acid (DNA or RNA); hepatitis G, direct probe technique | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 1 | CCS Clinical Classification | 206 - Microscopic examination (bacterial smear, culture, toxicology) |
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| 2011-01-01 | Changed | Short description changed. |
| 1998-01-01 | Added | First appearance in code book in 1998. |
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