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The CPT® Code 87528 refers to the detection of infectious agents, specifically the Herpes simplex virus (HSV), through nucleic acid techniques that identify either DNA or RNA. This procedure utilizes a direct probe technique to ascertain the presence of HSV in a specimen. Herpes simplex virus is primarily transmitted through direct contact, and the initial infection often manifests as ulcerations on the skin or mucous membranes. After the primary infection, HSV can enter a latent state within the body and may reactivate due to various triggers, including other illnesses, infections, or stress. Individuals at heightened risk for severe complications from HSV include neonates and those with compromised immune systems, as they may develop infections affecting the eyes or central nervous system. There are two distinct types of HSV: type 1, which is commonly associated with oral herpes (cold sores) but can also lead to genital infections, and type 2, which primarily causes genital herpes. The testing process involves obtaining a specimen from an oral or genital lesion, the vitreous humor of the eye, or a blood sample. In the context of CPT® Code 87528, the specimen undergoes a specific incubation process with lysate to break down cells and release nucleic acids. Following this, probes that are specific to HSV-1 and/or HSV-2 are introduced to the sample, allowing for the detection of the virus. The results can indicate the presence of either type of HSV, which is crucial for diagnosis and subsequent management of the infection.
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The procedure associated with CPT® Code 87528 is indicated for the detection of Herpes simplex virus (HSV) in patients who present with symptoms or conditions suggestive of an HSV infection. The following are specific indications for performing this test:
The procedure for CPT® Code 87528 involves several detailed steps to ensure accurate detection of the Herpes simplex virus. The following outlines the procedural steps:
After the completion of the procedure associated with CPT® Code 87528, the results are analyzed and reported. The expected outcome is a clear indication of whether HSV-1 or HSV-2 is present in the specimen. Clinicians may use this information to guide treatment decisions and patient management. It is important to note that if both HSV-1 and HSV-2 are tested, the appropriate codes for the direct or amplified probe must be reported for each serotype. Additionally, if quantification of the viral load is performed, the corresponding quantification procedure code should also be reported. Patients may be advised on follow-up care based on the results, particularly if an active infection is confirmed.
| Short Descr | HSV DNA DIR PROBE | Medium Descr | IADNA HERPES SIMPLX VIRUS DIRECT PROBE TQ | Long Descr | Infectious agent detection by nucleic acid (DNA or RNA); Herpes simplex virus, direct probe technique | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 1 | CCS Clinical Classification | 206 - Microscopic examination (bacterial smear, culture, toxicology) |
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| 2011-01-01 | Changed | Short description changed. |
| 1998-01-01 | Added | First appearance in code book in 1998. |
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