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The CPT® Code 87560 refers to a laboratory test designed for the detection of the infectious agent Mycobacteria avium-intracellulare (MAI) through the use of nucleic acid techniques, specifically targeting DNA or RNA. Mycobacteria avium-intracellulare is part of the Mycobacteria avium complex (MAC), which consists of two species of gram-positive, acid-fast, atypical bacteria that are often indistinguishable from one another. These bacteria are commonly found in environmental sources such as water and soil, and they can also be carried by birds and farm animals. Infections caused by MAI primarily affect the lungs, leading to a range of symptoms that may include a productive cough with significant sputum production, fever, weight loss, fatigue, and night sweats. The direct probe technique utilized in this test involves identifying a specific nucleic acid sequence, known as the target sequence, that is unique to the MAI organism. This detection can occur in various biological samples, including blood, tissue, cerebrospinal fluid (CSF), or synovial fluid. The probe used in this technique is labeled with either fluorescent or chemiluminescent markers, allowing for the visualization of the hybrid formed when the probe binds to the target sequence. The process includes treating the sample to release nucleic acids from the target organism, if present, and then the labeled probe specifically binds to the matching target sequence, forming a stable hybrid. Ribosomal RNA is often the focus of this detection method due to its abundance in microorganisms, as it is typically present in thousands of copies compared to the limited copies of genomic DNA. This method is distinct from the amplified probe technique, which significantly enhances assay sensitivity by exponentially amplifying the target sequence of MAI DNA or RNA, often utilizing polymerase chain reaction (PCR) or reverse transcriptase polymerase chain reaction (RT-PCR) for this purpose. The amplified sequences can then be identified using labeled DNA probes, and further quantification of these nucleic acids can provide insights into the number of microorganisms present in the sample.
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The CPT® Code 87560 is indicated for the detection of Mycobacteria avium-intracellulare (MAI) in patients who may be exhibiting symptoms consistent with an MAI infection. The following conditions and symptoms warrant the use of this laboratory test:
The procedure for CPT® Code 87560 involves several critical steps to ensure accurate detection of Mycobacteria avium-intracellulare. The following outlines the procedural steps:
After the completion of the procedure associated with CPT® Code 87560, the laboratory will analyze the results and report the findings to the requesting physician. It is essential for the healthcare provider to interpret the results in conjunction with the patient's clinical symptoms and history. Depending on the outcome, further diagnostic testing or treatment may be warranted. Patients may not require specific post-procedure care related to the test itself, but they should be monitored for any ongoing symptoms or complications related to the suspected infection. Follow-up consultations may be necessary to discuss the results and potential treatment options based on the findings of the test.
| Short Descr | M.AVIUM-INTRA DNA DIR PROB | Medium Descr | IADNA MYCOBACTERIA AVIUM-INTRACLRE DIR PRB | Long Descr | Infectious agent detection by nucleic acid (DNA or RNA); Mycobacteria avium-intracellulare, direct probe technique | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 1 | CCS Clinical Classification | 206 - Microscopic examination (bacterial smear, culture, toxicology) |
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| 2011-01-01 | Changed | Short description changed. |
| 1998-01-01 | Added | First appearance in code book in 1998. |
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