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The CPT® Code 87562 refers to a laboratory test designed for the detection of the infectious agent Mycobacteria avium-intracellulare (MAI) through the analysis of nucleic acids, specifically DNA or RNA. Mycobacteria avium-intracellulare is part of the Mycobacteria avium complex (MAC), which consists of two species of gram-positive, acid-fast, atypical bacteria that are often indistinguishable from one another. These bacteria are commonly found in environmental sources such as water and soil, and they can also be carried by birds and farm animals. Infections caused by MAI primarily affect the lungs and can lead to a range of symptoms including a productive cough with significant sputum production, fever, weight loss, fatigue, and night sweats. The testing process involves a direct probe test that identifies a unique nucleic acid sequence, known as the target sequence, of the MAI organism if it is present in various biological samples such as blood, tissue, cerebrospinal fluid (CSF), or synovial fluid. This probe is labeled with either fluorescent or chemiluminescent markers to facilitate detection. The sample undergoes treatment to release nucleic acids from the target organism, allowing the labeled probe to specifically bind to the matching target sequence, forming a stable hybrid. Ribosomal RNA is typically the focus of these tests due to its abundance in microorganisms, as it exists in thousands of copies compared to the limited copies found in genomic DNA. To enhance the sensitivity of the assay, an amplified probe technique is employed, which involves exponentially multiplying the target sequence of MAI DNA or RNA into millions of copies. The most prevalent amplification methods include polymerase chain reaction (PCR) and reverse transcriptase polymerase chain reaction (RT-PCR). Following amplification, the replicated sequences are identified using labeled DNA probes. The quantification aspect of this test, as indicated by CPT® Code 87562, provides an assessment of the number of microorganisms present in the sample. Quantitative or real-time PCR is often utilized to amplify the isolated nucleic acid segment, generating reports that document the absolute or relative amounts of the known nucleic acid sequence at each stage of the testing process.
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The CPT® Code 87562 is indicated for the detection and quantification of Mycobacteria avium-intracellulare (MAI) in patients who may be experiencing symptoms associated with MAI infection. The following conditions and symptoms warrant the use of this laboratory test:
The procedure for CPT® Code 87562 involves several critical steps to ensure accurate detection and quantification of Mycobacteria avium-intracellulare. The process begins with the collection of a biological sample, which may include blood, tissue, cerebrospinal fluid (CSF), or synovial fluid. Once the sample is obtained, it undergoes treatment to release nucleic acids from any present MAI organisms. This step is crucial as it prepares the sample for the subsequent detection process.
After the completion of the procedure associated with CPT® Code 87562, the laboratory will analyze the results and generate a report detailing the presence and quantity of Mycobacteria avium-intracellulare in the sample. Clinicians will review these results to determine the appropriate course of action for the patient, which may include further diagnostic testing, treatment options, or monitoring of the patient's condition. It is essential for healthcare providers to communicate the results to the patient and discuss any necessary follow-up care or additional testing that may be required based on the findings. Additionally, proper documentation of the procedure and results is crucial for compliance and billing purposes.
| Short Descr | M.AVIUM-INTRA DNA QUANT | Medium Descr | IADNA MYCOBACTERIA AVIUM-INTRACELLULARE QUANT | Long Descr | Infectious agent detection by nucleic acid (DNA or RNA); Mycobacteria avium-intracellulare, quantification | Status Code | Statutory Exclusion (from MPFS, may be paid under other methodologies) | Global Days | XXX - Global Concept Does Not Apply | PC/TC Indicator (26, TC) | 9 - Not Applicable | Multiple Procedures (51) | 9 - Concept does not apply. | Bilateral Surgery (50) | 9 - Concept does not apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 9 - Concept does not apply. | Co-Surgeons (62) | 9 - Concept does not apply. | Team Surgery (66) | 9 - Concept does not apply. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | CLIA Waived (QW) | No | APC Status Indicator | Conditionally packaged laboratory tests | Type of Service (TOS) | 5 - Diagnostic Laboratory | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 1 | CCS Clinical Classification | 206 - Microscopic examination (bacterial smear, culture, toxicology) |
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| 2011-01-01 | Changed | Short description changed. |
| 1998-01-01 | Added | First appearance in code book in 1998. |
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