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Official Description

Infectious agent antigen detection by immunoassay with direct optical (ie, visual) observation; Neisseria gonorrhoeae

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 87850 refers to the detection of infectious agent antigens through an immunoassay method, specifically targeting Neisseria gonorrhoeae, the bacterium responsible for gonorrhea. Gonorrhea is a sexually transmitted infection (STI) that can be transmitted through direct contact during sexual activities, affecting various anatomical sites including the reproductive tract, mouth, throat, eyes, and anus. In women, Neisseria gonorrhoeae often remains asymptomatic, which can lead to severe complications such as pelvic inflammatory disease (PID) and infertility due to potential irreversible damage to the reproductive system. Conversely, men typically exhibit symptoms such as burning sensations during urination, itching, and discharge from the urethra; however, they are less likely to experience long-term reproductive issues from the infection. The testing process involves collecting a specimen using a swab from the cervix, male urethra, mouth, throat, or eye, or alternatively, a urine sample may be utilized. The test itself is a rapid, qualitative sandwich immunoassay that identifies the presence of gonorrhea antigens in the specimen. During the procedure, the specimen is mixed with a reagent that extracts the gonorrhea antigen, followed by the application of monoclonal and polyclonal antibodies that specifically bind to Neisseria gonorrhoeae. A positive result is indicated by a color change in the test strip, line, or dot, alongside a control strip, line, or dot, confirming the presence of the antigen.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The procedure associated with CPT® Code 87850 is indicated for the detection of Neisseria gonorrhoeae in patients who may be exhibiting symptoms of gonorrhea or are at risk for sexually transmitted infections. The following conditions warrant the use of this test:

  • Asymptomatic Screening Patients, particularly women, who are asymptomatic but at risk for gonorrhea due to sexual history or exposure.
  • Symptomatic Patients Individuals presenting with symptoms such as urethral burning, discharge, or pelvic pain, which may suggest a gonococcal infection.
  • Follow-Up Testing Patients who have previously tested positive for gonorrhea and require follow-up testing to confirm the resolution of the infection after treatment.
  • High-Risk Populations Individuals in high-risk groups, including those with multiple sexual partners or a history of STIs, may be routinely screened for gonorrhea.

2. Procedure

The procedure for CPT® Code 87850 involves several key steps to ensure accurate detection of Neisseria gonorrhoeae. The following outlines the procedural steps:

  • Specimen Collection A specimen is collected using a swab from the appropriate anatomical site, which may include the cervix in females, the male urethra, or other sites such as the throat or eyes. Alternatively, a urine sample may be obtained. Proper collection techniques are essential to ensure the integrity of the specimen.
  • Specimen Preparation The collected specimen is then placed into a tube containing a specific reagent designed to extract the gonorrhea antigen from the sample. This step is crucial as it prepares the specimen for the subsequent immunoassay.
  • Immunoassay Process The prepared specimen is subjected to a rapid qualitative sandwich immunoassay. Monoclonal and polyclonal antibodies are introduced to the specimen, which specifically bind to the Neisseria gonorrhoeae antigens if present. This binding is a critical part of the detection process.
  • Result Interpretation After the immunoassay is completed, the test strip, line, or dot is observed for color changes. A positive result is indicated by a color change in the test strip, line, or dot, alongside a control strip, line, or dot, confirming the presence of the gonorrhea antigen in the specimen.

3. Post-Procedure

Post-procedure care for patients undergoing the CPT® Code 87850 test typically involves providing the patient with the results and any necessary follow-up actions. If the test result is positive, the patient should be informed about the need for treatment and potential implications for sexual partners. Counseling on safe sexual practices and the importance of notifying partners may also be recommended. In cases of negative results, patients may still be advised to continue regular screenings, especially if they are in high-risk categories. Additionally, healthcare providers should document the test results and any follow-up plans in the patient's medical record to ensure continuity of care.

Short Descr N. GONORRHOEAE ASSAY W/OPTIC
Medium Descr IAADIADOO NEISSERIA GONORRHOEAE
Long Descr Infectious agent antigen detection by immunoassay with direct optical (ie, visual) observation; Neisseria gonorrhoeae
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 1
CCS Clinical Classification 206 - Microscopic examination (bacterial smear, culture, toxicology)
Date
Action
Notes
2022-01-01 Changed First appearance of change in codebook.
2021-01-01 Changed First appearance of change in CPT® Code Set.
2020-10-06 Changed Code description changed.
2009-01-01 Changed Code description changed.
1998-01-01 Added First appearance in code book in 1998.
Code
Description
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