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Official Description

Infectious agent genotype analysis by nucleic acid (DNA or RNA); cytomegalovirus

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 87910 refers to the process of conducting an infectious agent genotype analysis specifically for cytomegalovirus (CMV) using nucleic acid techniques, which can involve either DNA or RNA. This procedure is particularly significant in the context of patients who have tested positive for a CMV infection. CMV is a prevalent virus that typically remains asymptomatic in individuals with healthy immune systems. However, in patients with compromised immune systems, such as organ transplant recipients or individuals living with HIV, CMV can lead to severe complications due to its ability to replicate unchecked. The genotype analysis involves amplifying specific segments of the viral DNA, which enhances the ability to detect and identify the virus's genetic makeup. This identification is crucial as it can yield valuable prognostic information and guide healthcare providers in selecting appropriate antiviral therapies tailored to the specific genotype of the virus present in the patient. The procedure requires obtaining a blood sample, which is performed through a venipuncture that is reported separately. The analysis of the serum or plasma is typically conducted using advanced techniques such as polymerase chain reaction (PCR) or sequencing methods, which are essential for accurate genotyping of the virus.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The procedure indicated by CPT® Code 87910 is performed under specific circumstances related to cytomegalovirus (CMV) infections. The following conditions warrant the use of this genotype analysis:

  • Positive CMV Infection A patient who has tested positive for cytomegalovirus, indicating the presence of the virus in their system.
  • Immunocompromised Status Patients with weakened immune systems, such as those who are organ transplant recipients or individuals living with HIV, who are at higher risk for severe CMV-related complications.
  • Need for Prognostic Information Situations where understanding the specific genotype of the CMV is necessary to predict the course of the infection and potential outcomes.
  • Antiviral Treatment Decisions Cases where identifying the specific genotype can influence the choice of antiviral therapies, ensuring that the treatment is tailored to the patient's specific viral strain.

2. Procedure

The procedure for CPT® Code 87910 involves several critical steps to ensure accurate genotype analysis of cytomegalovirus. The following outlines the procedural steps:

  • Step 1: Patient Preparation The patient is prepared for the procedure, which may include explaining the process and obtaining informed consent. It is essential to ensure that the patient understands the purpose of the blood test and what to expect.
  • Step 2: Venipuncture A blood sample is obtained through a venipuncture, which is a standard procedure for drawing blood. This step is crucial as it provides the necessary specimen for testing. The site is typically cleaned and sterilized to prevent infection.
  • Step 3: Sample Collection The collected blood is placed in appropriate containers, such as serum or plasma tubes, which are designed to preserve the integrity of the nucleic acids for subsequent analysis.
  • Step 4: Laboratory Analysis The laboratory performs the analysis using polymerase chain reaction (PCR) or sequencing techniques. These methods amplify the viral DNA or RNA, allowing for the detection and identification of the specific CMV genotype present in the sample.
  • Step 5: Interpretation of Results Once the analysis is complete, the results are interpreted by qualified laboratory personnel. The identification of the specific genotype provides valuable information regarding the infection and potential treatment options.

3. Post-Procedure

After the procedure associated with CPT® Code 87910, the patient may be monitored for any immediate reactions to the venipuncture, although complications are rare. The results of the genotype analysis will typically be communicated to the healthcare provider, who will discuss the findings with the patient. Based on the genotype identified, the provider may recommend specific antiviral treatments or further monitoring, especially in immunocompromised patients. It is essential for the healthcare team to ensure that the patient understands the implications of the results and any necessary follow-up actions. Additionally, proper documentation of the procedure and results is crucial for compliance and billing purposes.

Short Descr NFCT AGT GNTYP ALYS CMV
Medium Descr NFCT AGT GENOTYPE ALYS NUCLEIC ACID CMV
Long Descr Infectious agent genotype analysis by nucleic acid (DNA or RNA); cytomegalovirus
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 1
CCS Clinical Classification 206 - Microscopic examination (bacterial smear, culture, toxicology)
90 Reference (outside) laboratory: when laboratory procedures are performed by a party other than the treating or reporting physician or other qualified health care professional, the procedure may be identified by adding modifier 90 to the usual procedure number.
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
91 Repeat clinical diagnostic laboratory test: in the course of treatment of the patient, it may be necessary to repeat the same laboratory test on the same day to obtain subsequent (multiple) test results. under these circumstances, the laboratory test performed can be identified by its usual procedure number and the addition of modifier 91. note: this modifier may not be used when tests are rerun to confirm initial results; due to testing problems with specimens or equipment; or for any other reason when a normal, one-time, reportable result is all that is required. this modifier may not be used when other code(s) describe a series of test results (eg, glucose tolerance tests, evocative/suppression testing). this modifier may only be used for laboratory test(s) performed more than once on the same day on the same patient.
Date
Action
Notes
2023-01-01 Note Short and medium descriptions changed.
2013-01-01 Added Added
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