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Official Description

Cytopathology, slides, cervical or vaginal (the Bethesda System); with manual screening and computer-assisted rescreening using cell selection and review under physician supervision

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The CPT® Code 88167 refers to a specific cytopathology procedure involving the analysis of cervical or vaginal slides using the Bethesda System. This procedure is commonly known as a Papanicolaou (PAP) smear, which is a screening test designed to detect abnormalities in cervical cells that could indicate the presence of precancerous conditions or cervical cancer. The Bethesda System is the standard reporting framework utilized in the United States for interpreting PAP smear results, providing a structured approach to categorize findings based on the adequacy of the sample and the presence of any cellular abnormalities. The results can indicate various conditions, including benign changes, atypical squamous cells of undetermined significance (ASCUS), atypical glandular cells of undetermined significance (AGCUS), dysplasia, or squamous intraepithelial lesions (SIL), which are further classified into low-grade (LGSIL) and high-grade (HGSIL) lesions, as well as carcinoma. During the procedure, cells are collected from the endocervix using a specialized instrument, such as a brush or stick, and then smeared onto a glass slide. The slide is subsequently fixed using either a spray or immersion method and is then covered with a coverslip. Once prepared, the slide is sent to a cytology laboratory where it undergoes staining to enhance the visibility of the cells under a microscope. A trained technician performs the initial screening of the slide, looking for any signs of abnormalities. In the case of CPT® Code 88167, the technician conducts a manual screening followed by a computer-assisted rescreening process. This involves the use of computer technology to identify suspicious single cells and abnormal cell structures, which the technician then reviews in conjunction with the manual findings. The comprehensive analysis ensures that any potential abnormalities are accurately identified and interpreted, with findings communicated to the treating physician for further action if necessary.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The procedure associated with CPT® Code 88167 is indicated for the following conditions:

  • Cervical Cancer Screening This test is performed as part of routine cervical cancer screening to detect any precancerous or cancerous changes in cervical cells.
  • Monitoring of Abnormal Findings It is indicated for patients with previous abnormal PAP smear results to monitor for any changes or progression of cellular abnormalities.
  • Evaluation of Symptoms The procedure may be indicated for patients presenting with symptoms such as abnormal vaginal bleeding, unusual discharge, or pelvic pain, which may warrant further investigation of cervical health.

2. Procedure

The procedure for CPT® Code 88167 involves several detailed steps to ensure accurate cytological evaluation:

  • Step 1: Sample Collection Cells are collected from the endocervix using a specialized instrument, such as a brush or stick. This step is crucial as it ensures that an adequate sample of cervical cells is obtained for analysis.
  • Step 2: Slide Preparation The collected specimen is then smeared onto a glass slide. The slide is fixed using either a spray or immersion technique to preserve the cellular structure for microscopic examination.
  • Step 3: Staining The prepared slide is sent to a cytology laboratory where it undergoes staining. This process enhances the visibility of the cells, allowing for better identification of any abnormalities during screening.
  • Step 4: Manual Screening A trained technician performs a manual screening of the stained slide under a microscope. This initial screening is essential for identifying any abnormal cells or cell clusters that may indicate pathology.
  • Step 5: Computer-Assisted Rescreening Following the manual screening, the slide is subjected to computer-assisted rescreening. The computer is programmed to detect suspicious single cells and abnormal cell structures, which aids in identifying potential issues that may have been missed during the manual screening.
  • Step 6: Review and Interpretation The technician reviews the findings from the computer-assisted analysis, carefully comparing them with the manual screening results. This thorough review process ensures that all potential abnormalities are accurately interpreted.
  • Step 7: Communication of Findings The results of the screening are communicated to the treating physician. If any abnormalities are detected, the pathologist may recommend further testing or follow-up procedures, such as a repeat PAP smear or additional diagnostic tests like colposcopy or biopsy.

3. Post-Procedure

After the procedure associated with CPT® Code 88167, the patient may be advised to follow up with their healthcare provider to discuss the results of the PAP smear. If the findings are abnormal, the physician may recommend a shorter follow-up interval for repeat testing or additional diagnostic procedures to further evaluate the cervical health. It is important for patients to adhere to any follow-up recommendations to ensure timely management of any identified issues. Additionally, the treating physician will provide guidance on any necessary lifestyle modifications or preventive measures based on the results of the screening.

Short Descr CYTOPATH TBS C/V SELECT
Medium Descr CYTP SLIDES C/V MNL SCR&CPTR RESCR CELL S&I
Long Descr Cytopathology, slides, cervical or vaginal (the Bethesda System); with manual screening and computer-assisted rescreening using cell selection and review under physician supervision
Status Code Statutory Exclusion (from MPFS, may be paid under other methodologies)
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 9 - Not Applicable
Multiple Procedures (51) 9 - Concept does not apply.
Bilateral Surgery (50) 9 - Concept does not apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 9 - Concept does not apply.
Co-Surgeons (62) 9 - Concept does not apply.
Team Surgery (66) 9 - Concept does not apply.
Diagnostic Imaging Family 99 - Concept Does Not Apply
CLIA Waived (QW) No
APC Status Indicator Conditionally packaged laboratory tests
Type of Service (TOS) 5 - Diagnostic Laboratory
Berenson-Eggers TOS (BETOS) T1H - Lab tests - other (non-Medicare fee schedule)
MUE 1
CCS Clinical Classification 234 - Pathology

This is a primary code that can be used with these additional add-on codes.

88155 Female Edit Addon Code MPFS Status: Statutory exclusion (from MPFS, may be paid under other methodologies) APC Q4 PUB 100 CPT Assistant Article Cytopathology, slides, cervical or vaginal, definitive hormonal evaluation (eg, maturation index, karyopyknotic index, estrogenic index) (List separately in addition to code[s] for other technical and interpretation services)
Date
Action
Notes
2013-01-01 Changed Medium Descriptor changed. Changed again per AMA 2013 corrections document.
2011-01-01 Changed Short description changed.
1999-01-01 Added First appearance in code book in 1999.
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