CPT® Code 88185

Add-On Code

Flow cytometry, cell surface, cytoplasmic, or nuclear marker, technical component only; each additional marker (List separately in addition to code for first marker)

Flow cytometry is a sophisticated laboratory technique utilized to analyze the characteristics of cells in a fluid suspension. This method involves the use of fluorescent markers that bind to specific cell surface, cytoplasmic, or nuclear components, allowing for the identification and quantification of various cell populations. The process begins with the collection of a sample, which can be whole blood, serum, or bone marrow. Once the sample is prepared, it is passed through a flow cytometer, an instrument that detects and measures the fluorescence emitted by the markers attached to the cells. This enables the laboratory to gather quantitative data regarding the different types of cells present in the sample. The CPT® Code 88185 specifically refers to the technical component of flow cytometry for each additional marker analyzed beyond the first. The first marker is reported separately using CPT® Code 88184. This coding structure allows for the detailed reporting of multiple markers in a single test, which is essential for comprehensive diagnostic evaluations. For instance, flow cytometry can be employed to assess B-Cell CD20 expression in patients undergoing treatment for certain lymphomas or leukemias, or to evaluate ZAP-70 levels in newly diagnosed chronic lymphocytic leukemia (CLL) patients. Additionally, it can be used to analyze T-cell populations for abnormalities, assess chimerism in post-bone marrow transplant patients, and diagnose hematopoietic neoplasms. The versatility of flow cytometry makes it a valuable tool in both clinical and research settings, providing critical insights into various hematological conditions.