CPT® Code 88264

CPT® Code 88264 refers to the procedure of chromosome analysis, specifically analyzing 20 to 25 cells. This analysis is typically performed using peripheral blood lymphocytes, skin, or solid tissue that has been cultured in a separately reportable procedure. The primary goal of this analysis is to evaluate the chromosomal composition of the sampled cells, which involves assessing the size, shape, and number of chromosomes present. Unlike other related codes, such as 88261, 88262, and 88263, which involve karyotyping and the analysis of a greater number of cells, CPT® 88264 focuses on the analysis of a smaller subset of cells without the detailed karyotyping process. This procedure is essential for identifying any extra, missing, or abnormal chromosome pieces that may be present in the sample. The normal chromosomal configurations for females and males are 46 XX and 46 XY, respectively. Chromosome analysis is a critical diagnostic tool in genetics, as it can reveal chromosomal abnormalities that may lead to various medical conditions, although the specific details of those conditions are not covered under this code.