CPT® Code 88267

Chromosome analysis is a laboratory procedure that examines the chromosomes in a sample of amniotic fluid or chorionic villus tissue. This analysis is typically performed to assess the chromosomal makeup of a fetus, particularly in cases where there are potential risks for chromosomal abnormalities. The procedure involves counting 15 cells and generating one karyotype, which is a visual representation of the chromosomes. The analysis is conducted using a technique known as banding, which enhances the visibility of the chromosomes under a microscope. This is crucial for identifying any abnormalities in the number or structure of chromosomes, which can lead to genetic disorders. The common indications for performing chromosome analysis include advanced maternal age, abnormal findings from prenatal ultrasounds, abnormal results from maternal blood screenings, a history of previous children with chromosomal abnormalities, known familial chromosome rearrangements, or known genetic disorders within the family. The process begins with the collection of amniotic fluid or chorionic villus samples, which are then processed in a laboratory setting to identify and analyze the chromosomes present in the cells. The normal chromosomal patterns for females and males are denoted as 46 XX and 46 XY, respectively, and any deviations from these patterns can indicate potential genetic issues that may require further investigation or intervention.